NCT06953440 The Effect of Dexamethasone Submucosal Injection After Surgical Extraction of Lower Impacted Third Molars on Trismus and Edema
| NCT ID | NCT06953440 |
| Status | Recruiting |
| Phase | Phase 4 |
| Sponsor | King Abdulaziz University |
| Condition | Swelling/ Edema |
| Study Type | INTERVENTIONAL |
| Enrollment | 66 participants |
| Start Date | 2024-02-01 |
| Primary Completion | 2025-05-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 4 studies follow an already-approved treatment in real-world conditions to monitor long-term safety and effectiveness.
This trial targets 66 participants in total. It began in 2024-02-01 with a primary completion date of 2025-05-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This clinical trial aims to investigate whether dexamethasone decreases edema and trismus in adults undergoing lower third molar surgical extraction. The main question it aims to answer is: Does dexamethasone submucosal injection have a positive impact on trismus and edema after third molar surgery compared to conventional postoperative prescription? Participants will: * Be administered with dexamethasone submucosal injection or a placebo after the surgery. * Visit the clinic three times the week after the extraction for follow-up.
Eligibility Criteria
Inclusion Criteria: * Patients with impacted lower third molars requiring surgical extraction. * Adults over the age of 18 years old. * American Society of Anaesthesiologists (ASA) 1, and ASA 2 Exclusion Criteria: * Patients with preoperative intraoral or extraoral swelling. * Patients requiring simple extraction (Class I group A according to Pell and ---Gregory classification). * Patients with uncontrolled systemic disease such as uncontrolled diabetic - patients. * Patients who are allergic to corticosteroids. * Patients who are contraindicated to use corticosteroids such as uncontrolled diabetic patients, and osteoporotic patients. * Patients who require extraction of additional teeth at the same visit.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06953440 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Swelling/ Edema. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06953440 trial and what does that mean for participants?
Phase 4 studies are conducted after a treatment has been approved. They monitor long-term safety and real-world effectiveness in a broader patient population.
Is NCT06953440 currently recruiting?
Yes, NCT06953440 is actively recruiting participants. Contact the research team at lbassyoni@kau.edu.sa for enrollment information.
Where is the NCT06953440 trial being conducted?
This trial is being conducted at Jeddah, Saudi Arabia.
Who is sponsoring the NCT06953440 clinical trial?
NCT06953440 is sponsored by King Abdulaziz University. The trial plans to enroll 66 participants.