NCT05839275 The Combination of Radiotherapy，Surufatinib and Sintilimab in High-Risk Localized Soft Tissue Sarcoma
| NCT ID | NCT05839275 |
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Sponsor | Fudan University |
| Condition | High-Risk Localized Soft Tissue Sarcoma |
| Study Type | INTERVENTIONAL |
| Enrollment | 52 participants |
| Start Date | 2022-08-01 |
| Primary Completion | 2024-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 52 participants in total. It began in 2022-08-01 with a primary completion date of 2024-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a prospective, single-center, single-arm, phase Ib/II clinical trial. The study aims to evaluate the safety and efficacy of the treatment which combines radiotherapy, Sintilimab (Anti-PD1 Antibody) and Surufatinib (small-molecule Tyrosine Kinase inhibitor) in patients with high-risk localized soft tissue sarcoma. There will be 52 patients with high-risk localized extremity and trunck soft tissue sarcoma recruited. The trail is designed as a two-stage study. In safety lead-in phase (phase Ib), using 3+3 design, 6 cycles of Surufatinib (250mg, 200mg, qd) and Sintilimab (200mg, q3w) will be applied. And radiotherapy (BED=50-60Gy (α/β=10)) will begin in week 4 of the therapy. In extended phase (phase II), Surufatinib will be applied in the recommended phase 2 dose (RP2D) according to phase Ib. And 200mg Sintilimab and radiotherapy will be applied as before. The dose-limiting toxicity (DLT) in phase Ib and objective response rate (ORR) in phase Ib+Phase II will be mainly analyzed.
Eligibility Criteria
Inclusion Criteria: * Aged from 18 to 70, with life expectancy more than 2 years * Histologically confirmed STS, G2 or G3 * Has imaging-confirmed localized lesions on the limbs or trunk without distant metastases * Has\>5 cm lesions, or the lesions are determined to be borderline resectable or unresectable by a multidisciplinary consultation. * Experience local recurrence after surgery (disease-free survival more than 2 months after surgery) or primary tumor * ECOG performance status 0-1 * Demonstrate adequate organ function (bone marrow, liver, kidney and clotting function) within 7 days before the first administration without using blood products or hematopoietic stimulating factors. * Fully informed and willing to provide written informed consent for the trial Exclusion Criteria: * The presence of regional or distant metastases detected by imaging evaluation * The following histological types: osteosarcoma, chordoma, classic chondrosarcoma, Kaposi's sarcoma, malignant mesothelioma, radiation-induced sarcomas * History of another primary malignant tumor within the past three years or at the same time (excluding localized basal cell carcinoma, cutaneous squamous cell carcinoma, ductal carcinoma in situ, lobular carcinoma in situ, adenocarcinoma in situ of cervix, or other previous malignant tumor with a disease-free survival of more than 10 years) * Receiving any other chemotherapy or targeted therapy within 4 weeks before enrollment * Prior treatment using anti-PD1 immunotherapy * Prior radiotherapy towards the target lesion or has other contraindications to radiotherapy or surgery * Baseline laboratory indicators do not meet the following criteria: neutrophils ≥1.5×10\^9/L, Hb≥90g/L, PLT≥100×10\^9/L , ALT ≤2.5 ULN, AST ≤2.5 ULN, Cr≤ 1.5 ULN or creatinine clearance rate \<50ml/min, TBIL ≤1.5 ULN, APTT≤1.5 ULN, PT ≤1.5 ULN * Urinary protein ≥ 2+, or 24-hour urine protein ≥1.0g/24h * Uncontrolled hypertension: SBP \>140mmHg or DBP \> 90mmHg * Uncontrolled hyperglycemia or coagulation disorder * Active infection requiring systemic anti-infective therapy * Uncontrolled mental diseases * Previous surgery within 2 weeks of before enrollment (excluding diagnostic biopsy or peripherally inserted central catheter implantation) * History of immunodeficiency diseases or active autoimmune disease requiring systemic treatment * Pregnant or lactating women * Allergic to any component of the therapy
Contact & Investigator
Zhen Zhang, M.D, PH.D
PRINCIPAL INVESTIGATOR
Fudan University
Frequently Asked Questions
Who can join the NCT05839275 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 70 Years, studying High-Risk Localized Soft Tissue Sarcoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05839275 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT05839275 currently recruiting?
Yes, NCT05839275 is actively recruiting participants. Contact the research team at wangxyyan@sina.com for enrollment information.
Where is the NCT05839275 trial being conducted?
This trial is being conducted at Shanghai, China.
Who is sponsoring the NCT05839275 clinical trial?
NCT05839275 is sponsored by Fudan University. The principal investigator is Zhen Zhang, M.D, PH.D at Fudan University. The trial plans to enroll 52 participants.