NCT06366399 The Acute T-Rex (Timing of Resistance Exercise) Study
| NCT ID | NCT06366399 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Utah |
| Condition | Diabetes Mellitus, Type 2 |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2023-11-15 |
| Primary Completion | 2025-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2023-11-15 with a primary completion date of 2025-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.
Eligibility Criteria
Inclusion Criteria: * Men and women, all ethnicities, aged 50-74 years * BMI ≥25 kg/m² and \<45 kg/m² * Weight stable (less than 5% change in the past 6 months) * Generally healthy individuals * Not meeting recommended activity guidelines for aerobic or resistance exercise Exclusion Criteria: * Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease * Cancer treatment in the past 5 years * Untreated thyroid disease or other medical conditions affecting weight or energy metabolism * Current use of weight loss medication or other medications likely to impact energy balance * Bariatric surgery or extensive bowel resection in the past 2 years * Current or recent history (past 2 years) of eating disorder * Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders * Non-English speaking * HbA1c \>6.5%
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06366399 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 74 Years, studying Diabetes Mellitus, Type 2. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06366399 currently recruiting?
Yes, NCT06366399 is actively recruiting participants. Contact the research team at tanya.halliday@utah.edu for enrollment information.
Where is the NCT06366399 trial being conducted?
This trial is being conducted at Salt Lake City, United States.
Who is sponsoring the NCT06366399 clinical trial?
NCT06366399 is sponsored by University of Utah. The trial plans to enroll 20 participants.
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