NCT06487663 TACE Combined With Immune Checkpoint Inhibitors for Liver Malignant Tumors
| NCT ID | NCT06487663 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Tianjin Medical University Cancer Institute and Hospital |
| Condition | Hepatocellular Carcinoma Non-resectable |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2020-10-27 |
| Primary Completion | 2025-10-27 |
Trial Parameters
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Brief Summary
This study will evaluate the efficacy and safety of TACE combined with immune checkpoint inhibitors to treat unresectable hepatocellular carcinoma.
Eligibility Criteria
Inclusion Criteria: * Confirmed diagnosis of HCC by histology/ cytology or clinical criteria * Sign informed consent * When screening for age, the age should be ≥ 18 years old * Eligible for TACE treatment * ECOG physical condition score is 0 or 1 * No prior systemic therapy for HCC, especially immunotherapy * According to the following mRECIST criteria, at least one measurable intrahepatic lesion is suitable for repeated evaluation Exclusion Criteria: * Have any history of kidney disease or nephrotic syndrome * Evidence of extrahepatic spread (EHS) * Cardiovascular diseases with clinical significance (such as activity), including unstable angina, ≥ grade 2 congestive heart failure, and arrhythmia with poor drug treatment control * Any condition representing a contraindication to TACE as determined by the investigators * Known genetic factors for bleeding or thrombosis; Any previous or current evidence indicating a tendency for bleeding * Individuals who have received immunotherapy (an
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