Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
Trial Parameters
Brief Summary
The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.
Eligibility Criteria
Inclusion Criteria: * Assigned female at birth * 18-70 years of age * Body mass index (BMI) \<30 kg/m2 Exclusion Criteria: * Assigned male at birth * Pregnancy, breastfeeding * Body mass index ≥30 kg/m2 * Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy * Current smoking/nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications