NCT07361406 SweetSpot - The Effect of Non-nutritive Sweeteners on Health
| NCT ID | NCT07361406 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Wageningen University |
| Condition | Healthy Adult |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-02-23 |
| Primary Completion | 2026-11-26 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2026-02-23 with a primary completion date of 2026-11-26.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and preference, and the excretion of NNS in urine.
Eligibility Criteria
Inclusion Criteria: * Age 45-79 years; * BMI of 20-35 kg/m2; * Having veins suitable for placement of a venflon catheter. Exclusion Criteria: * Diseases or prior surgeries affecting the stomach, liver, kidneys or intestines (allowed i.e. appendectomy); * Cardiovascular diseases (e.g. heart failure) or cancer (e.g. non-invasive skin cancer allowed); * Diagnosed with type 1 or type 2 diabetes; * Drug treated thyroid diseases (well substituted hypothyroidism is allowed for inclusion); * HbA1c level \>6.5% (\>48 mmol/mol), as measured during the screening visit; * Anaemia defined as Hb concentrations \<8.5 mmol/L for men and \<7.5 mmol/L for women via finger prick; * Regular use of/receiving medication interfering with research outcomes (as judged by research physician), such as use of glucose lowering drugs, insulin, or use of medication that impacts the gastro-intestinal system; * Use of antibiotics over the last 3 months before study start; * Donated blood within 2 months prior to the screening; * Food allergies, intolerances (including lactose/gluten intolerance) for products used in the study design and/or dietary restrictions interfering with the study (including special diets and eating disorders); * Followed a diet that can interfere with the study outcomes within 1 month prior to the screening (e.g. ketogenic, sugar free, carbohydrate free); * Not willing to eat all products in the study diet, including eggs and dairy. Vegetarian is possible; * Not willing to consume non-nutritive sweeteners; * Not willing to quit the use of supplements that can interfere with the study outcomes (e.g. pre- or probiotics). * Intention to change the intensity of exercise during the study period or planning to join a intensive sport event (e.g. marathon or triathlon); * Intention to lose or gain weight; * Working night shifts regularly; * Smoking regularly * Use of soft and/or hard drugs (cannabis included); * Abuse of alcohol (defined as \>14 glasses (women) or \>21 glasses (men) of alcoholic beverages per week); * Being pregnant or lactating or planning to become pregnant; * Inability to understand study information and/or communicate with staff; * Participation in another study that involves an intervention within two months prior to the intervention; * Working or doing a thesis/internship at the division of Human Nutrition \& Health, or the Food, Health \& Consumer Research group of Wageningen Food \& Biobased Research.
Frequently Asked Questions
Who can join the NCT07361406 clinical trial?
This trial is open to participants of all sexes, aged 45 Years or older, up to 79 Years, studying Healthy Adult. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07361406 currently recruiting?
Yes, NCT07361406 is actively recruiting participants. Visit ClinicalTrials.gov or contact Wageningen University to inquire about joining.
Where is the NCT07361406 trial being conducted?
This trial is being conducted at Wageningen, Netherlands.
Who is sponsoring the NCT07361406 clinical trial?
NCT07361406 is sponsored by Wageningen University. The trial plans to enroll 60 participants.