Study on the Effect of Combined Estrogen and Progestogen Therapy on Endometrial Repair After Induced Abortion
Trial Parameters
Brief Summary
Induced abortion is a common method to terminate pregnancy, but during the operation, it is necessary to dilate the cervix and aspirate the uterine cavity. Repeated induced abortions may increase the risk of uterine damage, leading to cervical stenosis or intrauterine adhesions, thinning of the endometrium, which may affect the implantation of fertilized eggs and the development of embryos, and ultimately may lead to infertility or miscarriage. This study aims to explore the effects of combined estrogen and progesterone on endometrial repair and ovarian function recovery after induced abortion.
Eligibility Criteria
Inclusion Criteria: * Age between 18 years old (inclusive) and 40 years old (inclusive) * Body Mass Index (BMI) ranging from 18.5Kg/㎡ to 23.9Kg/㎡ * Experienced at least 2 abortions or had a missed abortion * Confirmed gestational age of no more than 10 weeks, and the ultrasonic examination within three days prior to the surgery shows a gestational sac (average of three diameters) of at least 1.0cm, with an embryo length of no more than 3.0cm * Normal preoperative examination results as per the "Clinical Diagnosis and Treatment Guidelines and Technical Operation Standards: Family Planning Volume (2017 Revision)" * Capable of regular follow-ups and willing to sign the informed consent form. Exclusion Criteria: * Individuals with contraindications to estrogen and progesterone therapy * History of uterine adhesions confirmed by hysteroscopy, or a history of uterine cavity surgery or uterine malformation correction * Subjects who require placement of an intrauterine device or administration