NCT07813169 Study on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in Depression
| NCT ID | NCT07813169 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Guo Wenbin |
| Condition | Major Depression |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-05-19 |
| Primary Completion | 2027-07-03 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2026-05-19 with a primary completion date of 2027-07-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to learn if the proposed intermittent theta burst stimulation (iTBS) protocol can effectively improve anhedonia symptoms in depressed patients. The stimulation targets in our protocol include (1) dual-target stimulation at the left dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC). (2) single-target stimulation at the left DLPFC. The main questions it aims to answer are: * Whether iTBS of dual-target stimulation (left DLPFC and OFC) can improve the symptoms of anhedonia and better than single-target stimulation at the left DLPFC? * Whether iTBS of the dual targets of left DLPFC and OFC can improve the symptoms of anhedonia by correcting the abnormal functional connectivity of DLPFC-NAc and OFC-sgACC, regulating the functional abnormalities of NAc and sgACC, and indirectly repairing the overall dysfunction of the reward circuit. * Researchers will compare dual-target stimulation to single-target stimulation and sham dual-target stimulation (a dedicated sham coil is utilized which produces an identical audible click and physical sensation) to see if the proposed iTBS protocol works to treat anhedonia. Participants will: * Take 6 sessions of dual-target iTBS or single-target iTBS every day, for 5 consecutive days. * Visit our hospital at 1 week, 4 weeks, and 8weeks after the iTBS treatment completion, for clinical evaluation and brain image examination.
Eligibility Criteria
Inclusion Criteria: 1. Aged 18-45 years, and right-handed; 2. Diagnosed with major depressive disorder (MDD) by at least two qualified psychiatrists, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), with a Montgomery-Åsberg Depression Rating Scale (MADRS) score ≥ 20 or a 17-item Hamilton Depression Rating Scale (HAMD-17) score ≥ 17; 3. Evaluated by a psychiatrist as having prominent anhedonia, and meeting the cutoff criteria on two self-report anhedonia scales, including a Snaith-Hamilton Pleasure Scale, Chinese version (SHAPS-C) score ≥ 20, or a Temporal Experience of Pleasure Scale, Chinese version (TEPS-C) score ≤ 76; 4. Medication type and dosage remained unchanged for at least 4 weeks prior to treatment initiation and throughout the study period; 5. MADRS item 10 score ≤ 4. Exclusion Criteria: 1. A history of epilepsy, seizures, stroke, or other serious organic brain diseases; 2. Presence of severe infectious diseases, malignant tumors, or other major unstable medical conditions; 3. Intellectual disability or developmental delay, presence of psychotic symptoms, or meeting the diagnostic criteria for other psychiatric disorders; 4. A history of substance abuse or psychoactive substance use; 5. Presence of intracranial implants (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes), or any other metallic objects in or near the head that cannot be safely removed (excluding dental fillings); 6. Contraindications to MRI or structural intracranial abnormalities detected on MRI; 7. Pregnant or breastfeeding women; 8. Receipt of electroconvulsive therapy (ECT) within the past 6 months, or transcranial magnetic stimulation (TMS) within the past 3 months; 9. Current daily use of lorazepam \> 2 mg (or an equivalent dose), or use of antiepileptic drugs at any dose; 10. Presence of strong suicidal ideation, or a MADRS item 10 score \> 4.
Contact & Investigator
Wenbin Guo, PhD
PRINCIPAL INVESTIGATOR
Second Xiangya Hospital of Central South University
Frequently Asked Questions
Who can join the NCT07813169 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 45 Years, studying Major Depression. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07813169 currently recruiting?
Yes, NCT07813169 is actively recruiting participants. Contact the research team at guowenbin76@csu.edu.cn for enrollment information.
Where is the NCT07813169 trial being conducted?
This trial is being conducted at Changsha, China.
Who is sponsoring the NCT07813169 clinical trial?
NCT07813169 is sponsored by Guo Wenbin. The principal investigator is Wenbin Guo, PhD at Second Xiangya Hospital of Central South University. The trial plans to enroll 60 participants.
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