NCT07461610 Stool Analysis After Sleeve Gastrectomy vs Gastric Bypass
| NCT ID | NCT07461610 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Cairo University |
| Condition | Morbid Obesity |
| Study Type | OBSERVATIONAL |
| Enrollment | 50 participants |
| Start Date | 2026-04-05 |
| Primary Completion | 2026-11 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 50 participants in total. It began in 2026-04-05 with a primary completion date of 2026-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to learn whether routine stool tests can detect changes in gut function 6 months after two common types of weight loss surgery: sleeve gastrectomy and gastric bypass (including mini gastric bypass and Roux-en-Y gastric bypass). The main questions it aims to answer are: Do stool tests show more signs of undigested food or carbohydrate malabsorption after gastric bypass compared to sleeve gastrectomy? Do signs of gut inflammation in stool (like fecal calprotectin) decrease after surgery, and does this relate to improvements in blood sugar and weight loss? Can simple stool test results at 6 months predict how much weight a person loses or how well their diabetes improves? Researchers will compare stool test results between the two surgery groups (sleeve gastrectomy vs. gastric bypass) to see if the type of surgery leads to different changes in gut health. Participants will: Provide a stool sample before surgery and again 6 months after surgery Provide a blood sample at the same time points to measure weight, blood sugar, and cholesterol Undergo their planned weight loss surgery as part of their regular medical care
Eligibility Criteria
Inclusion Criteria: * Male and female patients aged 18 to 60 years * Body Mass Index (BMI) ≥ 40 kg/m², OR BMI ≥ 35 kg/m² with at least one obesity-related comorbidity (type 2 diabetes, hypertension, dyslipidemia, osteoarthritis, obstructive sleep apnea) * Patients scheduled for primary laparoscopic bariatric surgery (either SG or Gastric Bypass \[MGB or RYGB\]) at Kasr Al-Ainy University Hospitals * Provision of written informed consent Exclusion Criteria: * Age \< 18 years or \> 60 years * Previous bariatric surgery or major gastrointestinal surgery (gastric, intestinal, or colorectal resection) * Chronic kidney disease (eGFR \< 60 mL/min/1.73m²) or previous renal transplant * Chronic liver disease (cirrhosis, chronic hepatitis) or liver failure * Chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis), celiac disease, or chronic pancreatitis * Active malignancy or history of chemotherapy/radiotherapy in the past 5 years * Pregnancy or breastfeeding * Chronic alcohol abuse or substance abuse * Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to stool sample collection (to avoid confounding effects on gut flora) * Acute gastrointestinal infection at the time of sample collection
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07461610 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Morbid Obesity. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07461610 currently recruiting?
Yes, NCT07461610 is actively recruiting participants. Contact the research team at Ahmed-eid@kasralainy.edu.eg for enrollment information.
Where is the NCT07461610 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT07461610 clinical trial?
NCT07461610 is sponsored by Cairo University. The trial plans to enroll 50 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.