NCT03781765 Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk
| NCT ID | NCT03781765 |
| Status | Recruiting |
| Phase | Phase 4 |
| Sponsor | Icahn School of Medicine at Mount Sinai |
| Condition | ADHD |
| Study Type | INTERVENTIONAL |
| Enrollment | 44 participants |
| Start Date | 2019-06-04 |
| Primary Completion | 2025-09-25 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
The study team will examine the effects of FDA approved stimulant and non-stimulant medications for ADHD, among youth with ADHD and with and without Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD), on reward systems of the brain using fMRI.
Eligibility Criteria
Inclusion Criteria: * Pre-pubertal (e.g. Tanner stage 1 or 2) * Age 7-12 inclusive * Signed consent/assent * Parent communicates sufficiently in English to provide informed consent and complete assessment instruments; * ADHD as determined by computerized DISC (C-DISC) parent interview * ADHD-Rating Scale-5 total score (interview with parent ) * SNAP ADHD total score (teacher) of 1.5 SD \> age/sex norms * CD or severe ODD: CD or ODD + 2 symptoms of CD on C-DISC * SNAP ODD/CD subscale (parent and teacher) 1.5 SD \> age/sex norms Exclusion Criteria: * Major neurological/medical illness * History of head injury * Fetal exposure to alcohol/drugs * Diagnosis of major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, generalized anxiety, social phobia, Tourette's Disorder, PTSD, autism spectrum disorder) * Current suicidal ideation or past history of suicide attempt * Wechsler Abbreviated Scale of Intelligence (WASI)75 score \<75 * Prior or current treatment with