Trial Parameters
Brief Summary
SCINC is an adaptive design Master protocol that seeks to determine if there is "sufficient promise" of beneficial effect of treatment combinations to enhance motor recovery in pre-specified strata of people with a spinal cord injury.
Eligibility Criteria
SCINC Inclusion Criteria: \- Person with SCI SCINC Exclusion Criteria: \- Proven contraindication to intervention RRULI: Appendix 1 (TIH + ET) study-specific inclusion criteria: * Adults \> 18 years of age * Able to independently ventilate * Chronic SCI (\>1 years post-injury or impairment onset) * Tetraplegia (C2-T1 level of injury) * Evidence of motor incomplete paralysis in the upper limb below the neurological level of injury * Have a documented management plan for their AD if it occurs. RRULI: Appendix 1 (TIH + ET) study-specific exclusion criteria: * Pregnancy * Medical instability, including current or recent (within the previous 6 weeks) infection or inflammation * Current or recent (within the previous 6 weeks) pressure ulcers or cutaneous lesions * Poorly controlled diabetes * An episode of AD in the previous 6 months that required medical intervention to resolve * Significant other neurological, psychiatric, pulmonary, cardiovascular, orthopaedic, or oncological conditions.