NCT07583498 Spasticity in SCI Following Acute Intermittent Hypoxia
| NCT ID | NCT07583498 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zev Rymer |
| Condition | Spinal Cord Injuries (SCI) |
| Study Type | INTERVENTIONAL |
| Enrollment | 10 participants |
| Start Date | 2026-03-17 |
| Primary Completion | 2027-03 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 10 participants in total. It began in 2026-03-17 with a primary completion date of 2027-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.
Eligibility Criteria
Inclusion Criteria: * Age \>= 18 * Non-progressive spinal Cord injury at least 6 months prior * Level of injury between C1-C8 * ISNCSCI ASIA classification C or D * Measurable Spasticity Exclusion Criteria: * Pre-existing hypoxic pulmonary disease * Positive Covid-Pneumonia diagnosis within 1 year of visit * Uncontrolled hypertension \>140/90 mmHg * Individuals who are currently pregnant/nursing or planning on becoming pregnant * Individuals with a tracheostomy or who utilize mechanical ventilation * A botulinum toxin injection to upper extremity musculature within the past 3 months * Currently taking Baclofen * Congestive Heart Failure * Cardiac arrhythmias * Uncontrolled diabetes mellitus * Chronic obstructive pulmonary disease * Emphysema * Severe Asthma * Previous myocardial infarction * Carotid/intracerebral artery stenosis * Orthopedic injuries or surgeries that impact the ability to use the upper extremity * History of Epilepsy
Contact & Investigator
William Z Rymer, MD, PhD
PRINCIPAL INVESTIGATOR
Shirley Ryan AbilityLab
Frequently Asked Questions
Who can join the NCT07583498 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Spinal Cord Injuries (SCI). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07583498 currently recruiting?
Yes, NCT07583498 is actively recruiting participants. Contact the research team at w-rymer@northwestern.edu for enrollment information.
Where is the NCT07583498 trial being conducted?
This trial is being conducted at Chicago, United States.
Who is sponsoring the NCT07583498 clinical trial?
NCT07583498 is sponsored by Zev Rymer. The principal investigator is William Z Rymer, MD, PhD at Shirley Ryan AbilityLab. The trial plans to enroll 10 participants.