NCT06443151 Role of Endothelial Function in SCI CVD Risk
| NCT ID | NCT06443151 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Craig Hospital |
| Condition | Spinal Cord Injuries |
| Study Type | OBSERVATIONAL |
| Enrollment | 60 participants |
| Start Date | 2024-09-01 |
| Primary Completion | 2027-03-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 60 participants in total. It began in 2024-09-01 with a primary completion date of 2027-03-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear. Doctors generally attributed the increased risk with weight gain and developing diabetes, but many studies have shown that even without these common factors, plaque in vessels is developing more often and faster. Endothelial cells are a single layer of cells that line all vessels in the body and plays an important role in vessel health. Damage to endothelial cells is known to lead to heart attacks and strokes. Past studies on endothelial cells of people with spinal cord injury have been unclear. The investigators have new data that these cells are unhealthy after spinal cord injury a measurement. This includes measuring endothelial health by directly altering its function using a catheter in the arm and measuring small particles in blood called endothelial microvesicles. If the project is successful, the investigators will learn important information on the health of endothelial cells after spinal cord injury. The investigators will also be able to use these markers of endothelial cell function to create treatments to improve vessel health and prevent heart attacks and strokes later in life in people with spinal cord injury.
Eligibility Criteria
Inclusion Criteria: * Men and women of all races, ethnic backgrounds\>18 years of age * Traumatic spinal cord injury (Sports, Assault, Transport, Fall, Other Traumatic Causes) * Time since injury (\> 12 months) * Paraplegia Motor Complete Injury (neurological level of injury at T2 or below, ASIA Impairment Scale A or B Exclusion Criteria: * History of high blood pressure * History cardiovascular disease (coronary artery disease, congestive heart failure, myocardial infarction, cerebrovascular accident). * History high cholesterol * History of Diabetes Type I or Type II * History of Obstructive Pulmonary Disease * History of Chronic Kidney or Liver Disease * History of Cancer * History of Autoimmune Disease (Thyroid Disease, Lupus, Rheumatoid Arthritis, etc). * History of smoking tobacco in the last 12 months * History of alcohol use
Contact & Investigator
Andrew Park, MD
PRINCIPAL INVESTIGATOR
Craig Hospital
Frequently Asked Questions
Who can join the NCT06443151 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 89 Years, studying Spinal Cord Injuries. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06443151 currently recruiting?
Yes, NCT06443151 is actively recruiting participants. Contact the research team at cmorey@craighospital.org for enrollment information.
Where is the NCT06443151 trial being conducted?
This trial is being conducted at Englewood, United States.
Who is sponsoring the NCT06443151 clinical trial?
NCT06443151 is sponsored by Craig Hospital. The principal investigator is Andrew Park, MD at Craig Hospital. The trial plans to enroll 60 participants.