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Recruiting Phase 3 NCT06961968

NCT06961968 Randomized Withdrawal Study in Patients With Schizophrenia

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Clinical Trial Summary
NCT ID NCT06961968
Status Recruiting
Phase Phase 3
Sponsor Vanda Pharmaceuticals
Condition Schizophrenia
Study Type INTERVENTIONAL
Enrollment 400 participants
Start Date 2025-05-14
Primary Completion 2027-11

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age 65 Years
Study Type INTERVENTIONAL
Interventions
iloperidoneplacebo

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

Phase 3 trials are large pivotal studies comparing the treatment to current standard of care or placebo. Your participation directly contributes to the evidence needed for regulatory approval.

This trial targets 400 participants in total. It began in 2025-05-14 with a primary completion date of 2027-11.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

The purpose of this research is to evaluate the efficacy of dosing iloperidone long-acting injection (LAI) compared to placebo in preventing the exacerbation of symptoms in patients with schizophrenia.

Eligibility Criteria

Inclusion Criteria: * Males or females 18 to 65 years of age (inclusive) * Diagnosed with schizophrenia per DSM-5 criteria * In need of ongoing psychiatric treatment Exclusion Criteria: * DSM-5 diagnosis of a psychiatric disorder other than schizophrenia that was the primary focus of treatment within the previous six months

Contact & Investigator

Central Contact

Vanda Pharmaceuticals Inc.

✉ clinicaltrials@vandapharma.com

📞 202-734-3400

Frequently Asked Questions

Who can join the NCT06961968 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Schizophrenia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

What phase is the NCT06961968 trial and what does that mean for participants?

Phase 3 trials are large-scale studies comparing the new treatment to existing standards of care or a placebo. They provide the evidence needed for regulatory approval. This trial targets 400 participants.

Is NCT06961968 currently recruiting?

Yes, NCT06961968 is actively recruiting participants. Contact the research team at clinicaltrials@vandapharma.com for enrollment information.

Where is the NCT06961968 trial being conducted?

This trial is being conducted at Rogers, United States, Costa Mesa, United States, Lemon Grove, United States, Oceanside, United States and 11 additional locations.

Who is sponsoring the NCT06961968 clinical trial?

NCT06961968 is sponsored by Vanda Pharmaceuticals. The trial plans to enroll 400 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology