NCT07651306 Radiographic Cortical Thickness of the Humerus in Detecting Post-Stroke Regional Bone Loss
| NCT ID | NCT07651306 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Istanbul Physical Medicine Rehabilitation Training and Research Hospital |
| Condition | Hemiparesis After Stroke |
| Study Type | OBSERVATIONAL |
| Enrollment | 65 participants |
| Start Date | 2026-02-22 |
| Primary Completion | 2026-06-25 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 65 participants in total. It began in 2026-02-22 with a primary completion date of 2026-06-25.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Post-stroke immobilization and reduced weight-bearing frequently lead to significant regional bone mineral density loss and asymmetry, particularly in the paretic upper extremity, which increases fracture risks. While Dual-Energy X-ray Absorptiometry (DXA) is the gold standard for evaluating systemic bone loss, it primarily focuses on axial or lower extremity sites and lacks universal accessibility. Since routine shoulder radiographs offer an opportunistic screening tool to evaluate regional bone quality without additional radiation , this study aims to compare proximal humerus cortical bone thickness between the paretic and non-paretic sides in stroke patients and assess its correlation with systemic DXA values to determine its clinical utility. This cross-sectional, observational study involves a retrospective data analysis of patients aged 18 and older who experienced a single unilateral stroke at least 6 months prior and present with clinical hemiparesis. Eligible participants must have concurrent standard anteroposterior shoulder radiographs and DXA measurements available from their routine clinical follow-ups. Patient demographic data, stroke characteristics, Brunnstrom stages, and systemic DXA measurements (femoral neck and lumbar spine T-scores and bone mineral density values) are systematically recorded for analysis. Cortical bone thickness measurements are performed using ImageJ software on standard radiographs at points 10 cm and 12 cm distal to the highest point of the humerus. To ensure reliability, measurements for both the paretic and non-paretic sides are conducted independently by two researchers who are completely blinded to the DXA results. Statistical analyses, including paired t-tests or Wilcoxon tests and Pearson or Spearman correlations, will be used to compare the sides and evaluate the relationship between radiographic cortical thickness and systemic bone density.
Eligibility Criteria
Inclusion Criteria: * Patients aged 18 years and older. * A documented history of a single unilateral stroke that occurred at least 6 months prior to evaluation. * Presence of clinical hemiparesis. * Availability of concurrent standard anteroposterior (AP) shoulder radiographs taken within 6 months post-stroke alongside systemic DXA measurements. Exclusion Criteria: * History of surgical intervention in either shoulder. History of a proximal humerus fracture. * Co-existing metabolic bone diseases, such as primary hyperparathyroidism or osteomalacia. * History of malignancy. * Documented history of corticosteroid use. * Imaging artifacts that compromise the accuracy of DXA measurements. * History of a secondary stroke.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07651306 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Hemiparesis After Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07651306 currently recruiting?
Yes, NCT07651306 is actively recruiting participants. Contact the research team at dr.alkimozkan@gmail.com for enrollment information.
Where is the NCT07651306 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07651306 clinical trial?
NCT07651306 is sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital. The trial plans to enroll 65 participants.
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