NCT07299981 Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study
| NCT ID | NCT07299981 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Sigmund Freud PrivatUniversitat |
| Condition | Ischemic Stroke |
| Study Type | OBSERVATIONAL |
| Enrollment | 200 participants |
| Start Date | 2026-02-01 |
| Primary Completion | 2027-04-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 200 participants in total. It began in 2026-02-01 with a primary completion date of 2027-04-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses. Quantitative net water uptake (NWU) has emerged as a biomarker indicating blood-brain barrier disruption and may better reflect the "tissue clock" than time alone. Low NWU is associated with favorable outcomes, whereas high NWU predicts poor outcomes and futile recanalization. The study aims to determine whether NWU measured on initial non-contrast CT is a treatment effect modifier for the IVT therapy.
Eligibility Criteria
Inclusion Criteria: * Acute ischemic stroke treated with intravenous thrombolysis * Imaging with non-contrast cranial CT on admission * Follow-up imaging with non-contrast cranial CT or MRI 12-24 hours after IVT * Final Infarct volume \> 5ml * ASPECTS available Exclusion Criteria: * Known use of oral anticoagulation (OAC) on admission * Preexisting ischemic infarction on admission non-contrast cranial CT * Patients with large vessel occlusion AIS who underwent mechanical thrombectomy * Low imaging quality precluding radiological measurements * Severe white matter lesions precluding radiological measurements * No ASPECTS
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07299981 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Ischemic Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07299981 currently recruiting?
Yes, NCT07299981 is actively recruiting participants. Contact the research team at marek.sykora@med.sfu.ac.at for enrollment information.
Where is the NCT07299981 trial being conducted?
This trial is being conducted at Vienna, Austria.
Who is sponsoring the NCT07299981 clinical trial?
NCT07299981 is sponsored by Sigmund Freud PrivatUniversitat. The trial plans to enroll 200 participants.
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