| NCT ID | NCT07500649 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National University of Singapore |
| Condition | Aging |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-07-01 |
| Primary Completion | 2027-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-07-01 with a primary completion date of 2027-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The global ageing population is increasingly affected by age-related diseases, which are challenging healthcare systems. Current treatments often extend lifespan without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process could prevent or delay multiple diseases, enhancing healthspan. Fucoidan, a sulfated polysaccharide from brown macroalgae, is a safe dietary supplement with Sirtuin-6 (SIRT6) activating properties, which are linked to longevity. Clinical studies have shown that it reduces inflammatory markers associated with biological aging and frailty and influences DNA methylation in vitro and in vivo; however, its effects on human DNA methylation remain unknown.
Eligibility Criteria
Inclusion Criteria: 1. 50-80 years males; 2. Resident of Singapore (citizenship or permanent residency is not required); 3. Prefrail according to Fried frailty phenotype score; 4. English-literate who can understand, read and write in English; 5. Individuals without severe cognitive impairment, as determined by PI judgment; 6. Apparently healthy and non-smokers having not more than 2 of the following conditions. If the conditions are present they have to be stable: * Hypertension, * Hyperlipidemia, * Hyperglycemia, * Osteopenia/osteoporosis, * Osteoarthritis, * COPD, * Type 2 diabetes. Subjects who agree to shave one day before each visit if he has dense facial hairs on their cheeks that could interfere with skin microbiome sampling. Exclusion Criteria: 1. Pre-existing or history of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke, peripheral vascular disease); 2. Current cancer or non-stable chronic obstructive pulmonary disease (COPD); 3. Use of anticoagulant medication; 4. Consuming seaweed more than 3 times a week; 5. Having hairiness, moles, tattoos, scars, irritated skin, etc. on the face which could influence the investigation; 6. Having used within the 3 past weeks for more than 3 consecutive days any systemic or topical drugs related to antibiotics or having planned to use these treatments during the study; 7. Having a positive serology for HIV, HEPATITIS B, HEPATITIS C\* \*Subjects will undergo a serology test, which will be conducted at baseline and at the end of the intervention visit. Only for subjects who accepted to undergo skin microbiopsy sampling; 8. Subject with any contra-indication for skin microbiopsies: * hypersensitivity or any serious reaction to local anesthesia; (lidocaine/prilocaine), local antibiotics, and antiseptics, * with inherited or acquired hemostasis disorders, * having had any treatment which may affect the blood coagulation and hemostasis (anti-coagulant medications…), * having a history of wound healing defects (hypertrophic scars, keloids…).
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07500649 clinical trial?
This trial is open to male participants only, aged 50 Years or older, up to 80 Years, studying Aging. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07500649 currently recruiting?
Yes, NCT07500649 is actively recruiting participants. Contact the research team at a.maier@nus.edu.sg for enrollment information.
Where is the NCT07500649 trial being conducted?
This trial is being conducted at Singapore, Singapore, Singapore, Singapore.
Who is sponsoring the NCT07500649 clinical trial?
NCT07500649 is sponsored by National University of Singapore. The trial plans to enroll 60 participants.