NCT07421882 PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)
| NCT ID | NCT07421882 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Singapore General Hospital |
| Condition | Out-Of-Hospital Cardiac Arrest |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2026-02-01 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2026-02-01 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.
Eligibility Criteria
Inclusion Criteria: 1. Out-of-hospital cardiac arrest (OHCA) of any rhythm attended by Singapore Civil Defence Force (SCDF) paramedics. 2. Return of spontaneous circulation (ROSC) achieved in the pre-hospital setting. 3. Age ≥16 years and ≤80 years. 4. Patient remains comatose after ROSC, with Glasgow Coma Scale (GCS) ≤8. Exclusion Criteria: 1. Age \>80 years. 2. Traumatic cause of cardiac arrest. 3. Tympanic temperature \<34°C at time of assessment. 4. Pregnant females. 5. Termination of resuscitation in the Emergency Department. 6. Withdrawal of life support within 24 hours of Coronary Care Unit (CCU) admission.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07421882 clinical trial?
This trial is open to participants of all sexes, aged 16 Years or older, up to 80 Years, studying Out-Of-Hospital Cardiac Arrest. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07421882 currently recruiting?
Yes, NCT07421882 is actively recruiting participants. Contact the research team at shir.lynn.lim@nus.edu.sg for enrollment information.
Where is the NCT07421882 trial being conducted?
This trial is being conducted at Singapore, Singapore.
Who is sponsoring the NCT07421882 clinical trial?
NCT07421882 is sponsored by Singapore General Hospital. The trial plans to enroll 50 participants.