NCT06820450 Pilot Study to Characterize the Endometriosis Steroidome and Its Link to Endocrine Disruptors and Vaginal Dysbiosis
| NCT ID | NCT06820450 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Nantes University Hospital |
| Condition | Endometriosis |
| Study Type | OBSERVATIONAL |
| Enrollment | 135 participants |
| Start Date | 2025-07-01 |
| Primary Completion | 2027-07-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 135 participants in total. It began in 2025-07-01 with a primary completion date of 2027-07-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Endometriosis is a systemic, steroid-dependent, inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, affecting approximately 10 % of women of childbearing age. The etiology and pathophysiology of endometriosis is not completely understood to support effective treatment and prevention strategies. Despite the steroid dependency, little is known concerning the underlying metabolism of estrogen and other tightly related steroids. Moreover, shortening the long diagnostic delays is a major priority in endometriosis research.
Eligibility Criteria
Inclusion Criteria: * Women aged 18 to 45 * Free, informed and written consent from the patient to participate in the study * Good understanding of the French language * Patient affiliated to or benefiting from a social security or similar scheme Specific inclusion criteria for each group: Group 1. Controls. * Women with no laparoscopically confirmed signs suggestive of deep endometriosis. * No clinico-biological criteria in favour of a diagnosis of endometriotic disease, nor any radiological signs (ultrasound or MRI) suggestive of endometriosis. Group 2. Cases of deep endometriosis. * Newly diagnosed women (less than 12 months). * Severe, deep endometriotic pathology with surgical indication (clinical examination, imaging tests, pre-operative findings). Exclusion Criteria: * Intercurrent diagnosis of pregnancy. * Presence of other hormone-dependent pathologies (e.g. breast cancer, PCOS). * Acute infection.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06820450 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 45 Years, studying Endometriosis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06820450 currently recruiting?
Yes, NCT06820450 is actively recruiting participants. Contact the research team at Stéphane.ploteau@chu-nantes.fr for enrollment information.
Where is the NCT06820450 trial being conducted?
This trial is being conducted at Nantes, France.
Who is sponsoring the NCT06820450 clinical trial?
NCT06820450 is sponsored by Nantes University Hospital. The trial plans to enroll 135 participants.