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Recruiting NCT06770049

NCT06770049 Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial

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Clinical Trial Summary
NCT ID NCT06770049
Status Recruiting
Phase
Sponsor Mayo Clinic
Condition Obesity
Study Type INTERVENTIONAL
Enrollment 228 participants
Start Date 2025-01-22
Primary Completion 2028-12

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age 65 Years
Study Type INTERVENTIONAL
Interventions
Standard Lifestyle Intervention (SLI) programPhenotype-tailored Lifestyle Intervention (PLI) program

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

This trial targets 228 participants in total. It began in 2025-01-22 with a primary completion date of 2028-12.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

The purpose of this study is to develop an evidence-based precision medicine approach for obesity that enhances weight loss and promotes weight loss maintenance.

Eligibility Criteria

Inclusion: • men or women between 18 to 65 years with obesity (BMI\>30kg/m2). Exclusion: * weight change greater than 3% in the previous 3 months * history of bariatric surgery and bariatric endoscopy * untreated psychiatric disorders including binge eating disorders and bulimia * current use of AOMs * history of use of medications affecting weight or energy intake or energy expenditure in the last 6 months * history of type 1 diabetes mellitus or uncontrolled medical conditions (e.g., uncontrolled hypertension) * women who are pregnant or plan to become pregnant, * any condition that limits their participation in the study * Principal Investigator discretion

Contact & Investigator

Central Contact

Megan Schaefer

✉ RSTWEIGHTLOSS@mayo.edu

📞 507-266-6004

Principal Investigator

Andres Acosta, MD,PhD

PRINCIPAL INVESTIGATOR

Mayo Clinic

Frequently Asked Questions

Who can join the NCT06770049 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Obesity. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT06770049 currently recruiting?

Yes, NCT06770049 is actively recruiting participants. Contact the research team at RSTWEIGHTLOSS@mayo.edu for enrollment information.

Where is the NCT06770049 trial being conducted?

This trial is being conducted at Rochester, United States.

Who is sponsoring the NCT06770049 clinical trial?

NCT06770049 is sponsored by Mayo Clinic. The principal investigator is Andres Acosta, MD,PhD at Mayo Clinic. The trial plans to enroll 228 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology