NCT05412810 Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).
| NCT ID | NCT05412810 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ohio State University |
| Condition | Mechanical Ventilation Complication |
| Study Type | OBSERVATIONAL |
| Enrollment | 200 participants |
| Start Date | 2023-03-01 |
| Primary Completion | 2026-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 200 participants in total. It began in 2023-03-01 with a primary completion date of 2026-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of this study is to identify and determine the levels of oxidized lipids and lipid mediators following exposure to oxygen supplementation during mechanical ventilation by oxidative lipidomics. The investigators will include patients with mechanical ventilation and have received FiO2=\>0.5 atleast 90 minutes and collected two sequential mini bronchoalveolar lavage on them 24 hours apart. Mass Spectrometry Lipid chromatography will be conducted and clinical data will be analyzed.
Eligibility Criteria
Inclusion Criteria: • Adults age =\> 18 and needing Mechanical ventilation in Intensive Care unit expected atleast for 48 hours Exclusion Criteria: * 1.Mechanical ventilation, only needed for performing procedures- bronchoscopy, esophagogastroduodenoscopy, colonoscopy, or others * 2)Chronic respiratory failure prior to admission; * 3)Hemoptysis or diffuse alveolar hemorrhage * 4)Medication use such as N acetyl cysteine; aspirin, fish oil supplements. * 5)Primary team prohibits bronchoscopy for a specific clinical indication or safety;
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05412810 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 110 Years, studying Mechanical Ventilation Complication. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05412810 currently recruiting?
Yes, NCT05412810 is actively recruiting participants. Contact the research team at sarah.karow@osumc.edu for enrollment information.
Where is the NCT05412810 trial being conducted?
This trial is being conducted at Columbus, United States.
Who is sponsoring the NCT05412810 clinical trial?
NCT05412810 is sponsored by Ohio State University. The trial plans to enroll 200 participants.