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Recruiting NCT05334979

NCT05334979 Oxalate and Citrate

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Clinical Trial Summary
NCT ID NCT05334979
Status Recruiting
Phase
Sponsor University of Chicago
Condition Kidney Stone
Study Type INTERVENTIONAL
Enrollment 50 participants
Start Date 2022-10-27
Primary Completion 2026-12-01

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age 70 Years
Study Type INTERVENTIONAL
Interventions
Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

This trial targets 50 participants in total. It began in 2022-10-27 with a primary completion date of 2026-12-01.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.

Eligibility Criteria

Inclusion Criteria: Stone formers: * Age 18-70 * History of at least one calcium-based kidney stone Non-stone formers (controls): * Age 18-70 * No history of kidney stone * 24-hour urine oxalate within lab normal (\<50mg/day) Exclusion Criteria: * History of primarily uric acid, cysteine, or struvite stones. * History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate. * Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period. * Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Frequently Asked Questions

Who can join the NCT05334979 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, up to 70 Years, studying Kidney Stone. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT05334979 currently recruiting?

Yes, NCT05334979 is actively recruiting participants. Visit ClinicalTrials.gov or contact University of Chicago to inquire about joining.

Where is the NCT05334979 trial being conducted?

This trial is being conducted at Chicago, United States.

Who is sponsoring the NCT05334979 clinical trial?

NCT05334979 is sponsored by University of Chicago. The trial plans to enroll 50 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology