NCT02397824 Orodental Manifestations of Rare Diseases
| NCT ID | NCT02397824 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Strasbourg, France |
| Condition | Rare Disease Orodontal |
| Study Type | OBSERVATIONAL |
| Enrollment | 1,300 participants |
| Start Date | 2015-01 |
| Primary Completion | 2035-12 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 1,300 participants in total. It began in 2015-01 with a primary completion date of 2035-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
OroDental anomalies are one of the phenotypical aspects of at least 900 rare diseases or syndromes affecting by definition less than 1 in 2000 individual within the population (almost 25 million persons in Europe). They are often described in association with other organs or system malformations, which is understandable, because the same genes and signalling pathways regulate the oral cavity formation or odontogenesis and the development of other organs. The various dental and orofacial anomalies can be classified by type (anomalies of tooth number, shape, size, structures of mineralized tissues, eruption, resorption, tumors; anomalies of oral mucosa; anomalies of tongue…), by signalling pathways and by syndrome families. These anomalies (for example hypodontia/oligodontia, amelogenesis imperfecta, dentinogenesis imperfecta…) become increasingly identified as diagnostic and predictive traits. Not only is it important to recognise, name appropriately and integrate these dysmorphic clues into the patient dysmorphology analysis but it is essential to synthesize the observations and confront them to existing data about similar orodental anomalies encountered in some of the corresponding mutant mouse models. Translational approaches in development and medicine, are relevant to gain understanding of molecular events underlying clinical manifestations and to enhance diagnostic accuracy. The aim of this study is to improve the knowledge, diagnosis and care of oral cavity pathologies encountered in rare diseases via the identification and gathering of national and international patient cohorts and to structure the molecular diagnosis behind these conditions via targeted next-generation sequencing assays. Data collection is implemented on validated accredited tools (databases) complying with the legal regulations about patient data protection and medical record collection. All information is anonymized. New effective diagnosis and therapeutic tools are being developed.
Eligibility Criteria
Inclusion Criteria: * Patient presenting with a rare disease * New patient or patient already known in the center * Child (in his primary dentition) or adult * Man or woman * Having signed a consent form or accepted to participate to the study * Patient affiliated to social security * Validation of the inclusion by the principal investigator looking at the patient file Exclusion Criteria: * Patient whose clinical diagnostic is not possible * Patient whose clinical file does not contain teeth photos * Patient who has not signed a consent form and accepted to participate to the study * Patient who is not affiliated to social security. * Non validation of the inclusion by the principal investigator looking at the patient file
Frequently Asked Questions
Who can join the NCT02397824 clinical trial?
This trial is open to participants of all sexes, studying Rare Disease Orodontal. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT02397824 currently recruiting?
Yes, NCT02397824 is actively recruiting participants. Visit ClinicalTrials.gov or contact University Hospital, Strasbourg, France to inquire about joining.
Where is the NCT02397824 trial being conducted?
This trial is being conducted at Strasbourg, France.
Who is sponsoring the NCT02397824 clinical trial?
NCT02397824 is sponsored by University Hospital, Strasbourg, France. The trial plans to enroll 1,300 participants.
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