NCT04787354 Optimal Duration of Oxaliplatin in Adjuvant XELOX for Gastric Cancer Patients (EXODOX)

Eligibility & Interventions

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What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

Phase 3 trials are large pivotal studies comparing the treatment to current standard of care or placebo. Your participation directly contributes to the evidence needed for regulatory approval.

This trial targets 976 participants in total. It began in 2021-11-01 with a primary completion date of 2024-12-31.

Brief Summary

This study aims to compare the efficacy and safety of reduced adjuvant XELOX treatment (4 cycles of XELOX followed by 4 cycles of capecitabine alone) to standard adjuvant XELOX treatment (8 cycles of XELOX).

Eligibility Criteria

Inclusion Criteria: * Histologically or cytologically confirmed gastric or gastroesophageal junction adenocarcinoma patients who underwent curative surgery (D1 beta or D2 resection) * Pathologically confirmed stage II, III patients (AJCC 8th edition) * Age 19 years and older * Eastern Cooperative Oncology Group (ECOG) performance status 0 or 2 * Adequate marrow function (ANC \> 1,500/uL, Platelet \>100,000/uL, Hb \> 8.0 g/dL, patients with chronic anemia who require intermittent blood transfusions can also participate in the study) * Adequate renal function, with serum creatinine \< 1.5 x upper limit of normal (ULN). * Adequate hepatic function with serum total bilirubin ≤ 1.5 x ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x ULN * Written, informed consent to the study Exclusion Criteria: * Female patients who are pregnant or breast-feeding * Positive pregnancy test at baseline (postmenopausal women should be amenorrhea for at least 12 months to be considered non-fertile) * Sexually active men and women who are not willing to implement contraception during study and until 3 months after discontinuation of study drug * Evidence of metastasis (including cytologically confirmed malignant ascites) * Prior systemic chemotherapy or radiation therapy for stomach cancer * Patients who have not recovered from serious complications of gastrectomy * History of other malignancies within the last 3 years (excluding adequately treated basal cell carcinoma of the skin, in situ cancer of the cervix, non-metastatic thyroid cancer) * A history of clinically significant uncontrolled seizures, central nervous system disorders, or mental disorders, which make it impossible to understand the informed consent or interfere with compliance with oral drug intake * Clinically significant (i.e., active) heart disease: e.g. unstable angina requiring medication, symptomatic coronary artery disease, congestive heart failure with NYHA grade II or higher, severe cardiac arrhythmias or acute coronary syndrome in the past 6 months (including myocardial infarction) * Lack of integrity or malabsorption syndrome in the upper gastrointestinal tract, which is likely to affect the absorption of study drug * Serious uncontrolled infection or other serious uncontrolled disease * History of allograft requiring immunosuppression therapy * Received any investigational drug or procedure within 4 weeks prior to randomization * Active viral infection (for hepatitis B carrier, patients can be registered if HBV-DNA titer is less than 20,000 IU/mL, and are allowed to use prophylactic antiviral agents by investigator's choice) * Active HIV infection * Patients with peripheral sensory neuropathy with functional impairment

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