NCT06892704 Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.
| NCT ID | NCT06892704 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Northwestern University |
| Condition | Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP) |
| Study Type | OBSERVATIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-05-01 |
| Primary Completion | 2027-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 30 participants in total. It began in 2025-05-01 with a primary completion date of 2027-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to learn what can predict the return of the sense of smell in patients with chronic rhinosinusitis with nasal polyps being treated with dupilumab. The main questions it aims to answer are: 1. Does obstruction of the olfactory cleft predict return of the sense of smell? 2. Do electrophysiological signals generated by breathing and sniffing behavior predict return of the sense of smell? Participants starting dupilumab will undergo assessment for their degree of olfactory cleft obstruction, and an electrophysiologic assessment of their olfactory cleft and be followed over 6 months of treatment with dupilumab.
Eligibility Criteria
* Well documented history of CRSwNP * BSIT age/sex classified as "abnormal" score * Self-reported stable olfactory deficit of moderate to severe quality \> 3 months * Prior endoscopic sinus surgery \>3 months, \<10 years prior
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06892704 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06892704 currently recruiting?
Yes, NCT06892704 is actively recruiting participants. Contact the research team at aditi.agarwal@northwestern.edu for enrollment information.
Where is the NCT06892704 trial being conducted?
This trial is being conducted at Chicago, United States.
Who is sponsoring the NCT06892704 clinical trial?
NCT06892704 is sponsored by Northwestern University. The trial plans to enroll 30 participants.