NCT05657405 Observational Study of Advanced Data Analytics in Genetic Conditions
| NCT ID | NCT05657405 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Human Genome Research Institute (NHGRI) |
| Condition | Genetic Conditions |
| Study Type | OBSERVATIONAL |
| Enrollment | 1,250 participants |
| Start Date | 2026-07-08 |
| Primary Completion | 2032-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 1,250 participants in total. It began in 2026-07-08 with a primary completion date of 2032-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Background: The genes a person is born with can sometimes cause serious diseases. Genetic diseases are rare, but they can have a big impact on the people they affect. Researchers have already made great strides in understanding how some genes cause disease. But they would like to have even better tools to analyze and understand genetic data. To create these new tools, they need to gather health and genetic data from a lot of people. Objective: This natural history study will gather medical information from people with genetic conditions. Eligibility: People of any age who (1) are known or suspected to have a genetic condition or (2) have a family member with a known or suspected genetic condition. Design: Participants will come to the clinic for up to 4 days. Tests to be performed will vary depending on the nature of each participant s health issue. The tests may include: Blood and saliva. Blood may be drawn from a vein; cells and saliva may be collected by rubbing the inside of the cheek with a swab. These would be used for genetic testing. Imaging scans. Participants may have X-rays or other scans of their bodies. They may lie still on a table while a machine records the images. Heart tests. Participants may lie still while a technician places a probe on their chest. They may also have stickers attached to wires placed on their chest. Photographs and recordings. Pictures may be taken of facial features, skin changes, or other effects of the genetic condition. Video and audio recordings may also be made. Some people may be able to participate via telehealth.
Eligibility Criteria
* INCLUSION CRITERIA: To be eligible to participate in the website-based data collection portion, individuals must be known or suspected to have a genetic condition, or to be the relative of a person with a known or suspected genetic condition, and be willing to consent to and share the requested information with the study team. Adults unable to provide consent must have a Legally Authorized Representative \[LAR\] (who can provide evidence of this status by providing guardianship paperwork, which will be verified) be able to provide consent. To be eligible for the Clinical Center-based portion of this study, an individual must meet all of the following criteria: * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, from age 0 to over 100 years of age (the NIH Clinical Center's age-based eligibility criteria will be followed for any individuals who come to the Clinical Center for participation such that individuals \<3 years of age will have a screening form submitted to the Pediatrics consult service, and admissions will follow current Clinical Center limits based on age such that admissions to 1NW generally have to be \> 2 years of age) * Either: * A person who is known or suspected to have a genetic condition based on medical and/or family history * A person who is a family member of a person known or suspected to have a genetic condition (and who is themselves not known or suspected to have a genetic condition) * Ability of subject (or Legally Authorized Representative \[LAR\], who can provide evidence of this status, as described above) to understand and the willingness to sign a written informed consent document. To be eligible for the virtual conversation portion of this study, an individual must meet all of the following criteria: * Stated willingness to comply with all study procedures and availability for the duration of the study * Either: * A person over 18 years of age who is known to have a genetic condition based on medical and/or family history * A parent or guardian of a person known to have a genetic condition (and who is themselves not known or suspected to have a genetic condition) * Ability of subject (or Legally Authorized Representative \[LAR\], who can provide evidence of this status, as described above) to understand and the willingness to sign a written informed consent document. EXCLUSION CRITERIA: Individuals who are pregnant will be excluded from the Clinical Center-based portion of the study. There are no other exclusionary criteria except that individuals will be excluded from participation in this study if they are unable or unwilling to participate. The PI/AI may decline to enroll a patient for reasons such as being medically unstable, residing in a hospital, or for any concerns arising after review of the laboratory and clinical data.
Contact & Investigator
Benjamin D Solomon, M.D.
PRINCIPAL INVESTIGATOR
National Human Genome Research Institute (NHGRI)
Frequently Asked Questions
Who can join the NCT05657405 clinical trial?
This trial is open to participants of all sexes, aged 1 Day or older, up to 120 Years, studying Genetic Conditions. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05657405 currently recruiting?
Yes, NCT05657405 is actively recruiting participants. Contact the research team at rebekah.waikel@nih.gov for enrollment information.
Where is the NCT05657405 trial being conducted?
This trial is being conducted at Bethesda, United States.
Who is sponsoring the NCT05657405 clinical trial?
NCT05657405 is sponsored by National Human Genome Research Institute (NHGRI). The principal investigator is Benjamin D Solomon, M.D. at National Human Genome Research Institute (NHGRI). The trial plans to enroll 1,250 participants.