NCT05993351 Objective Concussion Assessment Using MRI and Metabolomics
| NCT ID | NCT05993351 |
| Status | Recruiting |
| Phase | — |
| Sponsor | St. Joseph's Healthcare Hamilton |
| Condition | Concussion, Brain |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2023-08-11 |
| Primary Completion | 2026-12-15 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2023-08-11 with a primary completion date of 2026-12-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects. Unfortunately, concussions can be hard to diagnose and many people have lasting post-concussion symptoms such as headaches, difficulty concentrating, and light sensitivity. Recent studies have shown that advanced magnetic resonance imaging (MRI) techniques can identify subtle brain changes caused by a concussion. This study aims to track concussions over time measuring MRI brain scans and post-concussion symptoms to gain a better understand how the brain is affected in comparison to symptoms.
Eligibility Criteria
Inclusion Criteria: * Aged between 9-50 * Recently sustained a concussion (within the last 2 weeks) Exclusion Criteria: * Aged 8 and younger or 51 and older * Unable to provide consent (e.g., poor English language skills, etc.) * History of liver or kidney disease * MRI contraindications: * Pacemaker * Stent * Joint prothesis * Implanted devices * Claustrophobia * Pregnant * Permanent piercings * Chronic/abusive use of alcohol and/or illicit drugs * Previous stroke or moderate/severe traumatic brain injury, subarachnoid hemorrhage, or intracranial hemorrhage * Healthy control participants must not have a concussion history or recently sustained a concussion
Contact & Investigator
Michael D Noseworthy, PhD, PEng
PRINCIPAL INVESTIGATOR
McMaster University
Frequently Asked Questions
Who can join the NCT05993351 clinical trial?
This trial is open to participants of all sexes, aged 9 Years or older, up to 50 Years, studying Concussion, Brain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05993351 currently recruiting?
Yes, NCT05993351 is actively recruiting participants. Contact the research team at nosewor@mcmaster.ca for enrollment information.
Where is the NCT05993351 trial being conducted?
This trial is being conducted at Hamilton, Canada.
Who is sponsoring the NCT05993351 clinical trial?
NCT05993351 is sponsored by St. Joseph's Healthcare Hamilton. The principal investigator is Michael D Noseworthy, PhD, PEng at McMaster University. The trial plans to enroll 100 participants.