NCT06113510 Non-invasive Coronary Thrombus Imaging to Define These Cause of Acute Myocardial Infarction
| NCT ID | NCT06113510 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Edinburgh |
| Condition | Myocardial Infarction |
| Study Type | OBSERVATIONAL |
| Enrollment | 80 participants |
| Start Date | 2025-01-06 |
| Primary Completion | 2026-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 80 participants in total. It began in 2025-01-06 with a primary completion date of 2026-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
We now have very sensitive blood tests that can pick up damage to the heart and find patients who have had a heart attack. However, whilst this is welcome, it does not identify what causes the heart attack and can sometimes pick up other conditions that cause a strain on the heart. The classic cause of a heart attack is when a blood clot forms on fatty deposits within the heart arteries. This leads to treating patients with blood thinning medication, and this is very effective and saves lives. However, many apparent heart attacks are not caused by blood clots and some may be caused by blood clots but pass unrecognised. In this proposal, we will test an exciting new imaging test that can 'see' from outside the body whether there is a blood clot in the heart arteries. This could provide a major new way of assessing patients to ensure they get the right diagnosis and the right treatment. This could ultimately improve the outcomes of or patients with heart attacks. We will recruit 80 patients in total who have recently been diagnosed with a heart attack from the cardiology department at the Royal Infirmary of Edinburgh. The research team will review patient's medical records to determine eligibility for the study. The research study involves participants undertaking the following research procedures and assessments: 1. A combined Positron Emission Tomography and Computed Tomography (PET-CT) scan of the heart 2. Ultrasound scan of the heart (Echocardiogram) 3. MRI scan of the heart 4. A blood test - a total of up to four tablespoons (60 mL) of blood will be taken for immediate testing and the remaining blood will be stored for future ethically approved studies 5. A follow up questionnaire 6 -12 months following the heart attack
Eligibility Criteria
Inclusion Criteria: * Males and females ≥ 18 years of age * Clinical presentation of chest pain, ST-segment deviation within a coronary artery territory on the electrocardiogram, raised cardiac troponin and non-obstructive coronary arteries on invasive coronary angiography as per international societal diagnostic criteria Exclusion Criteria: * \<18 years of age * Takatsubo cardiomyopathy * Myocarditis * Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2) * Woman of child-bearing potential who are pregnant or breastfeeding * Known allergy or contraindication to iodinated contrast or radiotracer * Patients unable to tolerate the supine position * Patients unable to provide informed consent
Frequently Asked Questions
Who can join the NCT06113510 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Myocardial Infarction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06113510 currently recruiting?
Yes, NCT06113510 is actively recruiting participants. Visit ClinicalTrials.gov or contact University of Edinburgh to inquire about joining.
Where is the NCT06113510 trial being conducted?
This trial is being conducted at Edinburgh, United Kingdom.
Who is sponsoring the NCT06113510 clinical trial?
NCT06113510 is sponsored by University of Edinburgh. The trial plans to enroll 80 participants.