NCT06992843 Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest
| NCT ID | NCT06992843 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Xiangya Hospital of Central South University |
| Condition | Cardiac Arrest |
| Study Type | INTERVENTIONAL |
| Enrollment | 1,008 participants |
| Start Date | 2025-10-22 |
| Primary Completion | 2027-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 1,008 participants in total. It began in 2025-10-22 with a primary completion date of 2027-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The investigators designed LAPTOPS to determine the effectiveness of a goal-directed neuroprotection bundles of active management including body temperature,PaCO2,PaO2,position,Blood glucose ,blood sodium,Blood pressure and Lactate vs. usual care in adult post-cardiac arrest care. LAPTOPS is a large-scale pragmatic clinical trial to provide reliable evidence over the effectiveness of a widely applicable goal-directed care bundle in acute phase of adult post-cardiac arrest care.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years and \< 80 years * Patients of in-hospital or out-of-hospital cardiac arrest who have returned -spontaneous circulation (ROSC) after cardiopulmonary resuscitation and do not require CPR for more than 20 minutes; * Patients who are unconscious after ROSC, defined as FOUR motor response score \< 4 points or GSC ≤ 8 points; * Family members or legal representatives signed informed consent. Exclusion Criteria: * Unwitnessed cardiac arrest, estimated time from cardiac arrest to start of CPR \> 30 minutes; * Time from cardiac arrest to ROSC \> 60 minutes; * Patients who woke up immediately after ROSC by CPR; * End-stage diseases; * Cardiac arrest considered to be caused by neurological diseases; * The patient was in a vegetative state before cardiac arrest; * The interval from the onset of cardiac arrest to enrollment is \>72 hours .
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06992843 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Cardiac Arrest. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06992843 currently recruiting?
Yes, NCT06992843 is actively recruiting participants. Contact the research team at zln7095@163.com for enrollment information.
Where is the NCT06992843 trial being conducted?
This trial is being conducted at Changsha, China.
Who is sponsoring the NCT06992843 clinical trial?
NCT06992843 is sponsored by Xiangya Hospital of Central South University. The trial plans to enroll 1,008 participants.