Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis
Trial Parameters
Brief Summary
This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network. The investigators will measure levels of a brain protein, Neurofilament light chain (Nfl), and assess changes in language using speech tests. Participants will have a single blood test and speech test, and will be followed up at 12-months to complete questionnaires and cognitive scales over the phone. The speech test will also be completed again at 12-months. Individuals at risk of a Fronto-temporal dementia syndrome will be eligible to complete optional genetic testing involving an 'at home' saliva sample.
Eligibility Criteria
Inclusion Criteria: * All patients presenting to Eastern Health services with a cognitive complaint or potential neurodegenerative disorder Exclusion Criteria: * Prognosis \<12 months * No cognitive complaint * Patients not involved within the single healthcare network