NCT05429463 Neoadjuvant Therapy of Sintilimab Combined With Chemotherapy for Resectable Squamous Cell NSCLC（neoSCORE Ⅱ）
| NCT ID | NCT05429463 |
| Status | Recruiting |
| Phase | Phase 3 |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Condition | Squamous Cell Non-small Cell Lung Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 250 participants |
| Start Date | 2022-11-11 |
| Primary Completion | 2025-11-11 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 3 trials are large pivotal studies comparing the treatment to current standard of care or placebo. Your participation directly contributes to the evidence needed for regulatory approval.
This trial targets 250 participants in total. It began in 2022-11-11 with a primary completion date of 2025-11-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a Phase 3, prospective, randomized, open-label, multi-center study that assesses the efficacy and safety of neoadjuvant therapy with different cycles of sintilimab combined with chemotherapy for Resectable Squamous Cell NSCLC. This trial will also explore the biomarkers of neoadjuvant immunochemotherapy.
Eligibility Criteria
Inclusion Criteria: 1. Sign the informed consent form before starting any trial related procedure.Be willingness and able to undergo planned visits, protocol therapy, laboratory tests and other testing procedures. 2. 18-75 years old, male or female. 3. Squamous Cell Non-small cell lung cancer confirmed by cytology or histology. 4. There must be at least one evaluable focus judged according to recist1.1 standard. 5. Evaluation by the researchers and classified by the 8th version of AJCC TNM staging to confirm resectable stage cⅡA-ⅢB squamous NSCLC patients without any treatment before. 6. ECOG PS 0-1. 7. Life expectancy \> 6 months. 8. Adequate organ function and it should meet the following criteria: Absolute value of neutrophils (ANC) ≥1.5×109/L in the absence of granulocyte colony stimulating factor for the past 14 days; Platelet ≥100×109/L in the last 14 days without blood transfusion; Hemoglobin \>9g/dL in the absence of blood transfusion or erythropoietin in the last 14 days ; Total bilirubin(TBIL)≤1.5ULN, ALT、AST≤ 2.5 ULN, serum creatinine(sCr)≤1.5ULN; Good blood coagulation: INR≤1.5 or PT≤1.5 ULN; Normal thyroid function: TSH within normal institutional limits; 9. For women of reproductive age, a urine or serum pregnancy test with negative results should be performed within 3 days prior to receiving the first study drug administration (day 1 of cycle 1). If a urine pregnancy test result cannot be confirmed as negative, a blood pregnancy test is requested. Women of nonreproductive age were defined as at least 1 year after menopause or having undergone surgical sterilization or hysterectomy. If there is a risk of conception, all subjects (both men and women) will use a medically approved highly effective contraceptive (e.g., an intrauterine device, birth control pill, or condom) for the entire treatment period up to 120 days after the last study drug (or 180 days after the last chemotherapy drug). Exclusion Criteria: 1. Malignancies within 5 years prior to the first dose(excluding radical skin basal cell carcinoma, skin squamous cell carcinoma and / or radical resection of carcinoma in situ). 2. Currently participating in the intervention clinical treatment, or receiving other drugs or research instruments within 4 weeks before the first dose. 3. Patients who have had prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, or drugs for another stimulation or synergistic inhibition of T cell receptor (e.g. CTLA-4, OX-40, CD137). 4. Active autoimmune diseases requiring systemic treatment (e.g. using disease improving drugs, corticosteroids or immunosuppressants) occurred within 2 years before the first dose. Alternative therapies (e.g. thyroxine, insulin or corticosteroids in physiological doses for adrenal or pituitary insufficiency) are not considered systemic treatment. 5. Systemic glucocorticoid therapy (excluding local glucocorticoids by nasal spray, inhalation or other routes) or any other form of immunosuppressive therapy is in progress within 7 days before the first dose. Note: it is allowed to use physiological dose of glucocorticoid (Prednisone≤10 mg/d or equivalent drug). 6. Received allogeneic organ transplantation (except corneal transplantation) or allogeneic hematopoietic stem cell transplantation. 7. Allergic to study drug(sintilimab, carboplatin, albumin-bound paclitaxel) components excipients. 8. Not fully recovered from toxicity and/ or complications caused by any intervention before treatment (≤level 1 or reach baseline, excluding fatigue or hair loss). 9. Has a known history of human immunodeficiency virus (HIV) infection (HIV 1/2 antibody positive). 10. Untreated active Hepatitis B (defined as HBsAg positive and HBV-DNA copies\>ULN). 11. Active Hepatitis C (HCV antibody positive and HCV-RNA level higher than the detection limit). 12. Inoculate the live vaccine within 30 days before the first dose (cycle 1 day 1). Note: it is allowed to receive the injection inactivated virus vaccine for seasonal influenza within 30 days before the first dose; however, it is not allowed to accept the live attenuated influenza vaccine for intranasal medication. 13. Pregnant or lactating women. 14. There are any serious or uncontrollable systemic diseases, such as: Resting ECG has significant abnormalities in rhythm, conduction or morphology, and the symptoms are serious and difficult to control,such as complete left bundle branch block, heart block above degree Ⅱ, ventricular arrhythmia or atrial fibrillation; Unstable angina, congestive heart failure, chronic heart failure with NYHA grade ≥ 2; Within 6 months before inclusion, there were any arterial thrombosis, embolism or ischemia, such as myocardial infarction, unstable angina, cerebrovascular accident, transient ischemic attack etc; History of noninfectious pneumonia requiring glucocorticoid treatment within 1 year before the first dose,or having currently clinical active interstitial lung diseases; Active pulmonary tuberculosis; Active or uncontrolled infections requiring systemic treatment; Liver diseases such as cirrhosis, decompensated liver disease, acute or chronic active hepatitis; Poorly controlled diabetes (Fasting blood glucose (FBG)\>10mmol/L); Urine routine test indicates that urine protein≥++, and confirmed that 24 hours proteinuria\>1.0 g; Patients with mental disorders who are unable to cooperate with the treatment; 15. There are medical history, disease, treatment or laboratory abnormal results that may interfere with the test results, prevent the subjects from participating in the whole process of the study, or the researchers think that participating in the study is not in the best interests of the subjects or there are other potential risks that the subjects are not suitable for the study.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05429463 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Squamous Cell Non-small Cell Lung Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05429463 trial and what does that mean for participants?
Phase 3 trials are large-scale studies comparing the new treatment to existing standards of care or a placebo. They provide the evidence needed for regulatory approval. This trial targets 250 participants.
Is NCT05429463 currently recruiting?
Yes, NCT05429463 is actively recruiting participants. Contact the research team at qiufuming@zju.edu.cn for enrollment information.
Where is the NCT05429463 trial being conducted?
This trial is being conducted at Hangzhou, China.
Who is sponsoring the NCT05429463 clinical trial?
NCT05429463 is sponsored by Second Affiliated Hospital, School of Medicine, Zhejiang University. The trial plans to enroll 250 participants.
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