Neoadjuvant Chemotherapy Plus Camrelizumab for FIGO Stage IB1 Cervical Cancer
Trial Parameters
Brief Summary
This multicenter, prospective clinical trial is designed to enroll PD-L1 expression-positive patients with stage IB1 cervical cancer who desire fertility preservation to undergo neoadjuvant chemotherapy in combination with a PD-1 inhibitor to evaluate the rate of complete pathologic remission, treatment-related adverse events, pregnancy rate, miscarriage rate, preterm birth rate, live birth rate, EFS and OS.
Eligibility Criteria
Inclusion Criteria: 1. Clinical diagnosis of stage IB1 cervical cancer after gynecologic examination and MRI evaluation by the investigator (FIGO 2018); 2. Pathologically confirmed diagnosis of cervical squamous cell carcinoma; 3. Transformation zone of TZ1 or TZ2 (IFCPC 2011); 4. Positive PD-L1 expression by preoperative pathology, i.e., Combined Positive Score (CPS) ≥1; 5. Patient age ≥18 years and ≤45 years; 6. ECOG score ≤1; 7. Laboratory tests: white blood cell (WBC) ≥3. 5×109/L, Neutrophil (NEU) ≥1. 5×109/L, platelet (PLT) ≥100×109/L, serum bilirubin ≤1.5 times the upper limit of normal, aminotransferase ≤1.5 times the upper limit of normal, and blood urea nitrogen （BUN) and Cr ≤normal; 8. Have a strong desire to give birth; 9. Willing to sign the informed consent form, including compliance with the requirements and restrictions listed in the informed consent form and program. Exclusion Criteria: 1. History of infertility, including those with infertility due to tubal or (and) hu