NCT07587632 Natural Cervical Ripening to Prevent Pharmacological Induction of Labor - a Pilot Study.
| NCT ID | NCT07587632 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Zurich |
| Condition | Pregnancy |
| Study Type | INTERVENTIONAL |
| Enrollment | 74 participants |
| Start Date | 2026-04-10 |
| Primary Completion | 2029-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 74 participants in total. It began in 2026-04-10 with a primary completion date of 2029-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
As of today, around 25% of all vaginal births happen after induction of labor (IOL). The internal guidelines of the University Hospital Zurich currently recommend pregnant women with a non-insulin dependent gestational diabetes an IOL around term. One possibility to prevent an IOL and increase the chance for a spontaneous onset of birth is a ripening of the cervix by alternative methods in an outpatient setting. The primary objective of this study is to evaluate the effect of natural cervical ripening methods on the time interval between 37 weeks (beginning of the intervention) and the onset of spontaneous labor.
Eligibility Criteria
Inclusion Criteria: * Singleton gestation * Non-insulin dependent, dietetically managed gestational diabetes * Greater than or equal to 34 weeks. * Planned vaginal birth at the University Hospital of Zurich * Planned IOL for 40 weeks of gestation. * Communication in German and/or English language possible. Exclusion Criteria: * Pregnant women with multiple gestation * Fetal macrosomia \>95th percentile * Intrauterine growth restriction \<3rd percentile * Already in labor (regular contractions or premature rupture of membranes (PROM) * Patients scheduled for IOL before 40 weeks * Insulin-dependent diabetes * Planned cesarean section * Planned birth in an external hospital * Inability to follow the procedures e.g. due to language problems, psychological disorders
Contact & Investigator
Verena Bossung, PD. Dr. med.
PRINCIPAL INVESTIGATOR
University of Zurich
Frequently Asked Questions
Who can join the NCT07587632 clinical trial?
This trial is open to female participants only, aged 18 Years or older, studying Pregnancy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07587632 currently recruiting?
Yes, NCT07587632 is actively recruiting participants. Contact the research team at verena.bossung@usz.ch for enrollment information.
Where is the NCT07587632 trial being conducted?
This trial is being conducted at Zurich, Switzerland.
Who is sponsoring the NCT07587632 clinical trial?
NCT07587632 is sponsored by University of Zurich. The principal investigator is Verena Bossung, PD. Dr. med. at University of Zurich. The trial plans to enroll 74 participants.