Trial Parameters
Brief Summary
This study is a phase IV, two-arm, randomized, double-blind, placebo-controlled study to assess whether individuals identified as primarily reward drinkers are significantly more likely to reduce heavy drinking if they receive XR-NTX than a matching placebo injection. Study subjects will receive monthly injections of long-acting injectable naltrexone 380 mg (4 mL) or matching placebo. All subjects will also receive 4 sessions of Medical Management (MM). Post-treatment follow-up visits will be conducted at 4 weeks after the scheduled completion of treatment.
Eligibility Criteria
Inclusion Criteria: * Age 18-65 years old * Willing to provide signed, informed consent and commit to completing the study procedures * Able to read at an 8th grade or higher level * Current DSM-5 diagnosis of AUD * Reports consuming 24+ standard drinks (men) or 18+ standard drinks (women) weekly on average over the month prior to consent * Expresses a desire to reduce or stop drinking and a willingness to receive two injections of study medication over 8 weeks of treatment. * Either a reward drinker \[i.e., an individual with a score of 19 or greater on the reward subscale and less than or equal to 18 on the relief subscale of the Inventory of Drinking Situations (IDS)\] or a relief drinker (i.e., an individual with a score of 21 or greater on the relief subscale and less than or equal to 18 on the reward subscale of the IDS). * Has a stable address in the local area; not planning to move; has documents for an ID check * Women of child-bearing potential (i.e., who have not had a hyste