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Recruiting NCT05816850

NCT05816850 Multilayer Biological Characterization of Advanced Follicular Lymphoma: a Translational Study From FIL_FOLL12 Trial

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Clinical Trial Summary
NCT ID NCT05816850
Status Recruiting
Phase
Sponsor Fondazione Italiana Linfomi - ETS
Condition Follicular Lymphoma
Study Type OBSERVATIONAL
Enrollment 654 participants
Start Date 2023-09-19
Primary Completion 2026-12-01

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age N/A
Study Type OBSERVATIONAL
Interventions
EZH2 mutations/CNAs by droplet digital PCR (ddPCR)EZH2-derived gene expression signature by RNA-Seq

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 654 participants in total. It began in 2023-09-19 with a primary completion date of 2026-12-01.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

This is a Multicenter, Retrospective, Biological study ancillary to FOLL12 trial to evaluate the role of EZH2 aberrations in patient with FL treated with immunochemotherapy. Moreover, several novel biomarkers of FL will be investigated.

Eligibility Criteria

Inclusion Criteria: * Patient enrolled in the FIL\_FOLL12 trial (documented by the signature of the study informed consent); * Availability of biological samples: bone marrow aspirate, peripheral blood and/or FFPE diagnostic sample (nodal or extranodal); Exclusion Criteria: * None

Contact & Investigator

Central Contact

Uffici Studi FIL

✉ startup@filinf.it

📞 +390131033153

Principal Investigator

Simone Ferrero, MD

PRINCIPAL INVESTIGATOR

SC Ematologia U - AOU Città della Salute e della Scienza di Torino

Frequently Asked Questions

Who can join the NCT05816850 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, studying Follicular Lymphoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT05816850 currently recruiting?

Yes, NCT05816850 is actively recruiting participants. Contact the research team at startup@filinf.it for enrollment information.

Where is the NCT05816850 trial being conducted?

This trial is being conducted at Alessandria, Italy, Biella, Italy, Brescia, Italy, Catania, Italy and 11 additional locations.

Who is sponsoring the NCT05816850 clinical trial?

NCT05816850 is sponsored by Fondazione Italiana Linfomi - ETS. The principal investigator is Simone Ferrero, MD at SC Ematologia U - AOU Città della Salute e della Scienza di Torino. The trial plans to enroll 654 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology