Multi-omics Study for Early Detection of Colorectal Cancer (MOED-CRC)
Trial Parameters
Brief Summary
The primary objective of the study is to screen multi-omics markers in blood samples and construct a prediction model for CRC based on liquid biopsy, and we will further optimize the prediction model by validating its clinical performance externally.
Eligibility Criteria
Inclusion Criteria for Case Arm: 1. Aged over 18 years. 2. Participants confirmed with colorectal adenocarcinoma or advanced adenoma through colonoscopy and pathological examination. 3. Provision of informed consent prior to any study specific procedures, sampling, and analyses. Inclusion Criteria for Control Arm: 1. Individuals of "General risk arm" should meet all the following criteria: 1. No history of colorectal adenomas or sessile serrated polyps. 2. No history of inflammatory bowel disease (8-10 years ). 3. No family history (first-degree relatives) of colorectal cancer. 2. Individuals of "High-risk arm" should meet at least one of the following criteria: 1. Asia-Pacific Colorectal Screening (APC) score ≥ 3. 2. Family history (first-degree relatives) of colorectal cancer. 3. History of positive fecal occult blood test. 4. Any 2 of the following: chronic diarrhea, chronic constipation, mucous bloody stools, history of psychological stimulation, history of chronic appendicitis or