Monitoring Drug Efficacy in Patients with Alzheimer's Disease
Trial Parameters
Brief Summary
This study will explore the different factors associated with drug response to acetylcholinesterase (AChE) inhibitor (donepezil) and NMDA receptor antagonist (memantine) in patients with Alzheimer's Disease.
Eligibility Criteria
Inclusion Criteria: * newly diagnosed with mild or moderate dementia using the Montreal Cognitive Assessment and Clinical Dementia Rating (CDR) performed by a licensed psychometrician * clinically diagnosed by an expert adult neurologist as having probable AD using the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria * treatment naive for any acetylcholinesterase inhibitors or memantine OR those who have not taken any acetylcholinesterase inhibitors or memantine in the last three months for any reasons except for adverse drug reaction * age 65 years old * residing in the National Capital Region * able to read and understand written and spoken English and Filipino Exclusion Criteria: * with structural or vascular causes of dementia other than subcortical lacunes (2 or less) as seen in plain CT scan * dementia diagnosis other than AD as determined by an expert adult neurologist * wi