NCT06134258 Mechanisms of Fasting Induced Reduction in Energy Expenditure
| NCT ID | NCT06134258 |
| Status | Recruiting |
| Phase | — |
| Sponsor | ETH Zurich |
| Condition | Fasting |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2023-11-15 |
| Primary Completion | 2026-04-18 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2023-11-15 with a primary completion date of 2026-04-18.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Fasting reduces the energy consumption of the human body. The extent of this adaptation varies significantly between different individuals. The aim of this research project is to investigate how this adaptation of the metabolism is regulated by the body. For this purpose, we will first measure how the so-called basal metabolic rate of the body reacts to a short-term fasting of 24 h in a preliminary study. Those subjects with a particularly pronounced and those subjects with an only slightly pronounced reaction of the basal metabolic rate will be invited to the main study. Here, in random order (24 h fasting vs. 8 h fasting), the following is compared * how the basal metabolic rate of the body reacts to the reduced energy intake. * how the energy metabolism increases after a test meal * what role in particular the thyroid hormones play in this adaptation. In addition, a sample of the subcutaneous adipose tissue is taken in each case and it is examined how the regulation of metabolic processes at the cellular level.
Eligibility Criteria
Inclusion Criteria: * Age: 18 to 40 years * Body mass index 18.0 to 27.0 kg/m² * Exclusion Criteria: * Chronic conditions necessitating medical treatment (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus), * Known or suspected non-compliance, drug or alcohol abuse, * Inability to follow the procedures of the study * Participation in another study with investigational drug within the 30 days preceding and during the present study, * Previous enrolment into the current study, * Enrolment of the investigator, his/her family members, employees and other dependent persons, * Hypothyroidism or hyperthyroidism * Pregnant, breastfeeding and menopausal women
Contact & Investigator
Matthias Betz
PRINCIPAL INVESTIGATOR
University Hospital, Basel, Switzerland
Frequently Asked Questions
Who can join the NCT06134258 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 40 Years, studying Fasting. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06134258 currently recruiting?
Yes, NCT06134258 is actively recruiting participants. Contact the research team at matthias.betz@usb.ch for enrollment information.
Where is the NCT06134258 trial being conducted?
This trial is being conducted at Basel, Switzerland.
Who is sponsoring the NCT06134258 clinical trial?
NCT06134258 is sponsored by ETH Zurich. The principal investigator is Matthias Betz at University Hospital, Basel, Switzerland. The trial plans to enroll 40 participants.