NCT06981351 Matching Treatments to Cognitive Deficits in Offenders With Substance Use Disorders
| NCT ID | NCT06981351 |
| Status | Recruiting |
| Phase | — |
| Sponsor | The Mind Research Network |
| Condition | Antisocial Behavior |
| Study Type | INTERVENTIONAL |
| Enrollment | 288 participants |
| Start Date | 2025-03-18 |
| Primary Completion | 2029-05-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 288 participants in total. It began in 2025-03-18 with a primary completion date of 2029-05-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to investigate the effect of two types of cognitive remediation training on real-world behavioral outcomes including substance use, institutional adjustment, and recidivism following release from prison. Each training type is designed to target one of two subtypes of antisocial criminal offenders, who are characterized by either: 1) Attention to context-based deficits, or 2) Affective cognitive control-based deficits. The main questions it aims to answer are: Does matching deficit type with targeted cognitive training improve outcomes (relative to mismatched training)? What are the functional brain mechanisms that underlie treatment change? Participants will: Be assigned to cognitive training that either does or does not match their deficit type. Complete six one-hour sessions of cognitive skills training. Complete pre and post-training behavioral tasks assessing self-regulation deficits. Complete structural MRI scans and functional MRI scans assessing cognitive control. Complete post-treatment follow-up assessments evaluating self-regulation, adjustment, and stressful life events, substance use and recidivism.
Eligibility Criteria
Inclusion Criteria: * Currently incarcerated * No uncorrectable auditory or visual deficits * Able to speak and/or understand English * 5th grade reading level or higher * IQ score = 80 or above * Lifetime history of substance use disorder based on DSM criteria * No history of dementia or other cognitive disability * No indication of current psychotic disorder * No major medical illness or CNS disease * Scores from the Psychopathy Checklist-Revised (PCL-R) meet criteria for one of the designated treatment groups Exclusion Criteria: \-
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06981351 clinical trial?
This trial is open to male participants only, aged 18 Years or older, up to 55 Years, studying Antisocial Behavior. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06981351 currently recruiting?
Yes, NCT06981351 is actively recruiting participants. Contact the research team at charenski@mrn.org for enrollment information.
Where is the NCT06981351 trial being conducted?
This trial is being conducted at Albuquerque, United States.
Who is sponsoring the NCT06981351 clinical trial?
NCT06981351 is sponsored by The Mind Research Network. The trial plans to enroll 288 participants.