NCT06202976 Mapping Epileptic Networks Using Multimodal Imaging
| NCT ID | NCT06202976 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Imagine Institute |
| Condition | Epilepsy in Children |
| Study Type | OBSERVATIONAL |
| Enrollment | 75 participants |
| Start Date | 2017-09-14 |
| Primary Completion | 2033-09-13 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 75 participants in total. It began in 2017-09-14 with a primary completion date of 2033-09-13.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations. To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI). It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery. The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.
Eligibility Criteria
Inclusion Criteria: * Be under 18 years of age on the day of inclusion. * Present with one of the following forms of epilepsy: * refractory focal lesional epilepsy * rare non-lesional epilepsy * Present abnormalities (spikes) on the intercritical EEG * Have been selected by the "Epilepsy" multidisciplinary staff. * In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup. * Be affiliated to a health insurance scheme. Exclusion Criteria: * Requiring general anesthesia for MRI * Require sedation specifically for research * Have generalized epilepsy * Be deprived of liberty or under guardianship.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06202976 clinical trial?
This trial is open to participants of all sexes, up to 18 Years, studying Epilepsy in Children. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06202976 currently recruiting?
Yes, NCT06202976 is actively recruiting participants. Contact the research team at nathalie.boddaert@aphp.fr for enrollment information.
Where is the NCT06202976 trial being conducted?
This trial is being conducted at Paris, France.
Who is sponsoring the NCT06202976 clinical trial?
NCT06202976 is sponsored by Imagine Institute. The trial plans to enroll 75 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.