Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking
Trial Parameters
Brief Summary
This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.
Eligibility Criteria
Inclusion Criteria: * Patient understands study procedures and is willing to participate in the study as indicated by the patient's signature * Provision of written, informed consent prior to any study specific procedures * Males and females aged 18-85 * Current or former cannabis smoker (medicinal or recreational) with or without concurrent tobacco smoking history * Participant is able to perform reproducible pulmonary function testing (i.e. the 3 best acceptable spirograms have Forced Expiratory Volume in 1 second (FEV1) values that do not vary more than 150 millilitres) * Participant is able to perform a breathhold for 16s * FEV1 \> 25% predicted * Forced Vital Capacity (FVC) \> 25% predicted and \>0.5 litres Exclusion Criteria: * Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material * Participant is medically unstable in the opinion of the Principal Invest