Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery
Trial Parameters
Brief Summary
This study aims to compare lidocaine and dexmedetomidine infusion and their combination on perioperative pain in patients undergoing video-assisted thoracoscopic surgery.
Eligibility Criteria
Inclusion Criteria: * Age ≥18 years old. * Both sexes. * American Society of Anesthesiologists (ASA) physical status of I, II. * Patients undergoing video-assisted thoracoscopic surgery (VATS) under general anesthesia. Exclusion Criteria: * Hypersensitivity to any of the used drugs. * Coagulation disorder. * Body mass index \>35 kg/m2. * History of chronic pain requiring daily opioids/steroids/clonidine/other α2 agonist/analgesics or any drugs acting on the central nervous system during the previous 2 weeks, and drug/alcohol abuse. * Contraindication to the use of local anesthetics. * Cardiovascular disease. * Severe respiratory, renal or hepatic impairment. * Insulin-dependent diabetes mellitus. * Central nervous system or psychiatric disease.