| NCT ID | NCT06271343 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Nantes University Hospital |
| Condition | Kidney Transplant Tolerance |
| Study Type | OBSERVATIONAL |
| Enrollment | 15 participants |
| Start Date | 2024-05-14 |
| Primary Completion | 2027-08-22 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 15 participants in total. It began in 2024-05-14 with a primary completion date of 2027-08-22.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Prospective experimental study using PBMC from a limited number of adult patients (15) treated at Nantes University Hospital for a kidney transplant from a related living donor. The study will be carried out on PBMC from both donors and recipients, collected during visits scheduled as part of the clinical management of the donor/recipient pair. The study will test the hypothesis that DP8α Tregs expressing CD73, whose frequency in blood increases stably after non-rejected kidney transplants, but not when patients have undergone or will subsequently undergo rejection, are enriched in donor-specific cells, which would be a strong argument in favor of a direct role for these Tregs in preventing transplant rejection, through their ability to inhibit immune responses directed against donor alloantigens.
Eligibility Criteria
Inclusion Criteria: * Adult donor-recipient pair. * First or second kidney transplant from a related ABO-compatible living donor. * BMI \< 35 for recipients. * Adult patients. * Patients weighing over 50 kgs. Exclusion Criteria: * Donor/recipient ABO incompatibility * BMI \> 35 for recipients
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06271343 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Kidney Transplant Tolerance. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06271343 currently recruiting?
Yes, NCT06271343 is actively recruiting participants. Contact the research team at christophe.masset@chu-nantes.fr for enrollment information.
Where is the NCT06271343 trial being conducted?
This trial is being conducted at Nantes, France.
Who is sponsoring the NCT06271343 clinical trial?
NCT06271343 is sponsored by Nantes University Hospital. The trial plans to enroll 15 participants.
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