NCT03481205 Ischemic Conditioning During Air tRansport Save penUmbral Tissue
| NCT ID | NCT03481205 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Enrique Leira |
| Condition | Acute Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 10 participants |
| Start Date | 2020-06-01 |
| Primary Completion | 2026-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 10 participants in total. It began in 2020-06-01 with a primary completion date of 2026-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to demonstrate the feasibility of performing remote limb ischemic conditioning (RLIC) using the Doctormate device, a special blood pressure device used to perform RLIC, on patients with acute ischemic stroke due to large vessel occlusion being transported to a thrombectomy capable center by the helicopter.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥18 and ≤ 80 years 2. Suspected acute ischemic stroke with symptoms suggestive of large vessel occlusion (aphasia, agnosia, neglect, visual field cut, and gaze preference). 3. Patient screened for rtPA, and rtPA administered if eligible 4. Subject or legally authorized representative able to provide consent at the time of the assessment 5. NIHSS 6-20 Exclusion Criteria: 1. Any intracranial hemorrhage (parenchymal, subarachnoid, subdural, epidural) on CT scan at the community hospital 2. History of upper or lower extremity ischemia, known subclavian, brachial artery, iliac or femoral artery stenosis, subclavian steal syndrome, any upper or lower extremity soft tissue, orthopedic or vascular injury, or mastectomy or other procedure that may contraindicate taking blood pressure or having a cuff on the arm or leg for the conditioning treatment 3. History of diabetes mellitus 4. Enrollment in another clinical trial 5. Patient incarcerated 6. Pregnancy. Patients ages 18-55 will need to have a negative urine or blood based pregnancy test. 7. Agitation deemed unsafe for ischemic preconditioning testing. 8. Arteriovenous fistula in upper limb
Contact & Investigator
Enrique Leira, MD
PRINCIPAL INVESTIGATOR
University of Iowa Hospitals and Clinics- 200 Hawkins Dr, Iowa City, IA 52242
Frequently Asked Questions
Who can join the NCT03481205 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Acute Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03481205 currently recruiting?
Yes, NCT03481205 is actively recruiting participants. Contact the research team at amir-shaban@uiowa.edu for enrollment information.
Where is the NCT03481205 trial being conducted?
This trial is being conducted at Iowa City, United States.
Who is sponsoring the NCT03481205 clinical trial?
NCT03481205 is sponsored by Enrique Leira. The principal investigator is Enrique Leira, MD at University of Iowa Hospitals and Clinics- 200 Hawkins Dr, Iowa City, IA 52242. The trial plans to enroll 10 participants.
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