NCT06787261 Involvement of Archaea in Carious Disease
| NCT ID | NCT06787261 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Assistance Publique Hopitaux De Marseille |
| Condition | Dental Caries |
| Study Type | INTERVENTIONAL |
| Enrollment | 200 participants |
| Start Date | 2026-02-19 |
| Primary Completion | 2027-02-19 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 200 participants in total. It began in 2026-02-19 with a primary completion date of 2027-02-19.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Dental caries is a major public health probleme the result of hard tissue demineralization and oral microbiota changes. Methanogenic archaea, mainly Methanobrevibacter oralis, are associated with various oral problems, including pathologies periodontal. Previous research has not really studied the Archaea in carious lesions, hence the importance of our study. Our study aims to explore their potential role in the the development of caries by analysing their prevalence and their quantification in relation to the carious risk individual. The aim is to improve understanding of the Cavity microbiology to advance management of this pathology in terms of prevention or of treatment. Our team is particularly competent in the field of Archaea, especially in the cultivation of Archaea methanogens since we have a dedicated platform. We also discovered the first human Nanoarchaea, opening up a whole new possible search field.
Eligibility Criteria
Inclusion Criteria: * Male or female of legal age. * Patient who is a beneficiary or entitled beneficiary of a social security * Patient under the care of the Restorative and Preventive Dentistry of the PROMOD - Timone Dentistry Unit. * Patients capable of giving written consent. Exclusion Criteria: Patient in a period of exclusion from another research protocol at the time of signing the consent form, Subjects covered by articles L1121-5 to 1121-8 of the Public Health public health code (minor patients, patients of full age under guardianship, patients deprived of their liberty, pregnant or breast-feeding), A person who does not have a sufficient command of reading and understanding of the French language to be able to consent to take part in the research Presence of periodontitis (gingivitis not being a criterion for a criterion for non-inclusion). Antibiotics taken in the previous month. Use of mouthwash in the previous 7 days.
Contact & Investigator
jean-olivier ARNAUD GENERAL DIRECTOR
STUDY DIRECTOR
Assistance Publique Hopitaux De Marseille
Frequently Asked Questions
Who can join the NCT06787261 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Dental Caries. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06787261 currently recruiting?
Yes, NCT06787261 is actively recruiting participants. Contact the research team at alexandra.giuliani@ap-hm.fr for enrollment information.
Where is the NCT06787261 trial being conducted?
This trial is being conducted at Marseille, France.
Who is sponsoring the NCT06787261 clinical trial?
NCT06787261 is sponsored by Assistance Publique Hopitaux De Marseille. The principal investigator is jean-olivier ARNAUD GENERAL DIRECTOR at Assistance Publique Hopitaux De Marseille. The trial plans to enroll 200 participants.