NCT06965946 Intermittent Hypoxia-Hyperoxia Combined With Physical Therapy for Knee Osteoarthritis
| NCT ID | NCT06965946 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Khyber Medical University Peshawar |
| Condition | Osteo Arthritis Knee |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-05-15 |
| Primary Completion | 2025-10-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-05-15 with a primary completion date of 2025-10-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized controlled trial aims to evaluate the effectiveness of combining intermittent hypoxia-hyperoxia therapy (IHHT) with conventional physical therapy in improving pain, function, gait, balance, and general health among patients with knee osteoarthritis. The study will be conducted at the Physical Therapy Department of Rehman Medical Institute, Peshawar, Pakistan, over a period of one year.
Eligibility Criteria
Inclusion Criteria: * Participants aged 45 and above. * Participants (both male and female) with knee pain for 3 months or more with any three of the following six items: age of 50 years or more, crepitations, enlarged bone, no palpable warmth, morning stiffness for less than 30 minutes, and bony tenderness. * Patients who can walk and have a minimum score of 4 on the Numeric Pain Rating Scale. * Participants who have intact cognition with a score of 24 and above on Mini Mini- Mental State examination. * Participants able to walk independently for at least 45 meters in the 6-minute walk test. * Participants having a recent X-ray (done within the past 3 months). Exclusion Criteria: * Patients with hip or knee arthroplasty. * Participants with above or below knee surgery or radiating pain to the lower limb. * Patients with history of epilepsy, pregnancy * Diagnosed neurological condition that affects lower-limb strength or walk (e.g., stroke/ basal ganglia dysfunction/ trauma) * Patients who refused to participate in the study or to be randomly allocated. * Patients receiving steroids or any medicine other than that prescribed by the screening orthopaedic surgeon.
Contact & Investigator
Dr Rida Shabbir, PhD
PRINCIPAL INVESTIGATOR
Institute of Physical Medicine and Rehabilitation, Khyber Medical University Peshawar
Frequently Asked Questions
Who can join the NCT06965946 clinical trial?
This trial is open to participants of all sexes, aged 45 Years or older, studying Osteo Arthritis Knee. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06965946 currently recruiting?
Yes, NCT06965946 is actively recruiting participants. Contact the research team at ridashabbir@kmu.edu.pk for enrollment information.
Where is the NCT06965946 trial being conducted?
This trial is being conducted at Peshawar, Pakistan.
Who is sponsoring the NCT06965946 clinical trial?
NCT06965946 is sponsored by Khyber Medical University Peshawar. The principal investigator is Dr Rida Shabbir, PhD at Institute of Physical Medicine and Rehabilitation, Khyber Medical University Peshawar. The trial plans to enroll 60 participants.