NCT06869486 Insomnia´s Impact on DNA Stability, Cardio-metabolic Health and Lifestyle Behaviors
| NCT ID | NCT06869486 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universidad Autonoma de Baja California |
| Condition | Insomnia |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2024-10-01 |
| Primary Completion | 2026-08-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2024-10-01 with a primary completion date of 2026-08-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Insomnia is a highly prevalent sleep disorder worldwide, with an increasing incidence in athletes, older adults, university students, and individuals with metabolic syndrome. This disorder has been associated with metabolic dysfunction, cardiovascular diseases, and genetic instability. Recent evidence suggests that insomnia negatively impacts cardiorespiratory fitness, insulin sensitivity, and overall health through mechanisms involving neuroendocrine dysregulation, oxidative stress, and alterations in energy metabolism. However, the specific biological and environmental factors that contribute to its prevalence and health consequences remain poorly understood, particularly across different populations. Understanding these associations is crucial for developing effective prevention and intervention strategies to mitigate the long-term impact of insomnia. Therefore, this study aims to analyze the impact of insomnia on body composition, cardiorespiratory fitness, metabolic flexibility, and DNA integrity, across populations with high prevalence of insomnia, including athletes, older adults, university students, and individuals with metabolic syndrome. This study will also investigate which biological and lifestyle behaviors contribute to insomnia and its health consequences. By doing so, this work will provide critical insights into the physiological and molecular mechanisms that link insomnia with metabolic and cardiovascular dysfunction, contributing to the development of targeted interventions for at-risk populations
Eligibility Criteria
Inclusion Criteria: Each population group will meet the following inclusion criteria: * Healthy Individuals (18-35 years old, men and women) * Waist circumference: \<90 cm (men), \<80 cm (women) * Fasting glucose: 70-110 mg/dL * Blood pressure: \<120/80 mmHg * Triglycerides: \<150 mg/dL * HDL-C: \>40 mg/dL (men), \>50 mg/dL (women) * Physical activity level: 600-1500 MET-min/week * Athletes (18-35 years old, men and women) \*Engaged in structured sports training with a physical activity level \>1500 MET-min/week * Older Adults (65-75 years old, men and women) \*Free of cognitive or mental health disorders. No specific cardiometabolic or body composition criteria due to the study's exploratory nature. * University Students (18-35 years old, men and women) \*No specific cardiometabolic or body composition criteria due to the study's exploratory nature. * Individuals with Metabolic Syndrome (18-35 years old, men and women) * Waist circumference: \>90 cm (men), \>80 cm (women) * Fasting glucose: \>110 mg/dL * Blood pressure: \>130/80 mmHg * Triglycerides: \>150 mg/dL * HDL-C: \<40 mg/dL (men), \<50 mg/dL (women) * Physical activity level: \<600 MET-min/week Exclusion Criteria: * Individuals with respiratory diseases or musculoskeletal injuries that prevent exercise, as determined by a clinical history review, a physical activity readiness questionnaire (PART-Q+), and pulmonary function tests (spirometry). Individuals with rotating or night-shift work schedules (e.g., emergency personnel, security guards), as circadian rhythm disruptions significantly impact sleep quality * Women diagnosed with polycystic ovary syndrome (PCOS) or showing high testosterone levels with a history of oligomenorrhea, as these conditions may influence metabolic and hormonal markers. However, women with menstrual irregularities related to premenstrual syndrome (PMS) or dysmenorrhea will not be excluded, given the established link between sleep disorders and menstrual cycle variations * This study does not involve chronic dietary or exercise interventions, nor does it require long-term participant follow-up, so no additional exclusion criteria apply
Contact & Investigator
Isaac A Chavez-Guevara, PhD
PRINCIPAL INVESTIGATOR
Universidad Autonoma de Baja California
Frequently Asked Questions
Who can join the NCT06869486 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Insomnia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06869486 currently recruiting?
Yes, NCT06869486 is actively recruiting participants. Contact the research team at irenteria@uabc.edu.mx for enrollment information.
Where is the NCT06869486 trial being conducted?
This trial is being conducted at Ensenada, Mexico.
Who is sponsoring the NCT06869486 clinical trial?
NCT06869486 is sponsored by Universidad Autonoma de Baja California. The principal investigator is Isaac A Chavez-Guevara, PhD at Universidad Autonoma de Baja California. The trial plans to enroll 300 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.