NCT05871606 Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy
| NCT ID | NCT05871606 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | Wake Forest University Health Sciences |
| Condition | Cerebrovascular Disorders |
| Study Type | INTERVENTIONAL |
| Enrollment | 36 participants |
| Start Date | 2026-04-16 |
| Primary Completion | 2028-08-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 36 participants in total. It began in 2026-04-16 with a primary completion date of 2028-08-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to determine the safety and feasibility of using inhaled nitric oxide (iNO) in patients undergoing intra-arterial mechanical thrombectomy (blood clot extraction or IAMT) for treatment of acute ischemic (non-bleeding) stroke (AIS).
Eligibility Criteria
Inclusion Criteria: * Age 18 and \< 80 * Clinical evidence of acute ischemic (non-bleeding) stroke (AIS) with NIH Stroke Scale of 6 or higher * Non-contrast Computed tomography (CT) Head with ASPECT (Alberta Stroke Program Early CT) score 6 * Symptom onset began \< 16 hours from initiation of intra-arterial mechanical thrombectomy (IAMT) procedure * CT Angiogram (CTA) evidence of anterior circulation MCA (Middle Cerebral Artery) M1 or dominant proximal M2 segment occlusion. * CT Perfusion (CTP) evidence of core infarct volume of \< 70ml and a ratio of ischemic tissue to initial core infarct volume of 1.8 or greater, and an absolute volume of penumbra of 15ml or greater * Patient or patient's representative provides consent * Pre-stroke modified Rankin Scale (mRS) of \< =2 * General endotracheal anesthesia (GETA) is planned to be used, as standard care, for IAMT * Treatment with iNO requires mechanical ventilation. Because IAMT can be performed using conscious sedation and not GETA, only those patients for which the procedure is planned with GETA will be included. The decision for the type of anesthetic depends on the severity of stroke, region of brain affected by the stroke, and the ability for the patient to cooperate for the procedure. Exclusion Criteria: * Hypotension at presentation, defined as systolic blood pressure (SBP) \< 100 or MAP \< 60; profound hypertension with SBP \>185 or DBP \>110mmHg unable to be controlled with IV medications * Inability to undergo a brain MRI (e.g., implanted pacemaker) * Patients who received IV tPA \>4.5hrs after symptom onset * Coaguloapathy, defined as platelet count \< 50,000, INR \>3.0, PTT \> 3x normal, use of novel anticoagulants with eGFR \< 30ml/min * Vulnerable Subjects including: mentally ill or incompetent patients, those with diminished decision-making capacity, prisoners, inpatient care for long-term chronic illness, terminally ill, pregnant women, and children * Any form of hemorrhage on non-contrast CT Head or mass lesion * Severe head injury within 90 days * Pre-existing severe neurological/psychiatric disease * Seizure at stroke onset (unable to assess NIHSS) * Blood glucose \< 50mg/dL or \>400mg/dL * Hemoglobin \<7mmol/L * eGFR \< 30ml/min * Allergy to contrast media * Presumed septic embolus as source of stroke * Flow limiting intracranial or extracranial carotid stenosis, or complete carotid occlusion
Contact & Investigator
William R Stetler, MD
PRINCIPAL INVESTIGATOR
Wake Forest University Health Sciences
Frequently Asked Questions
Who can join the NCT05871606 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Cerebrovascular Disorders. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05871606 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT05871606 currently recruiting?
Yes, NCT05871606 is actively recruiting participants. Contact the research team at anna.m.helms@advocatehealth.org for enrollment information.
Where is the NCT05871606 trial being conducted?
This trial is being conducted at Charlotte, United States, Charlotte, United States.
Who is sponsoring the NCT05871606 clinical trial?
NCT05871606 is sponsored by Wake Forest University Health Sciences. The principal investigator is William R Stetler, MD at Wake Forest University Health Sciences. The trial plans to enroll 36 participants.