NCT06842784 Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
| NCT ID | NCT06842784 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Texas Southwestern Medical Center |
| Condition | Aging |
| Study Type | OBSERVATIONAL |
| Enrollment | 24 participants |
| Start Date | 2025-02-03 |
| Primary Completion | 2026-02-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 24 participants in total. It began in 2025-02-03 with a primary completion date of 2026-02-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as myocardial infarction. Previous data indicate that older adults have attenuated skin blood flow and sweating responses when exposed to heat, resulting greater increase in core body temperature. Despite these observations, relatively little is known about the risk for myocardial ischemia potentially contributing to the aforementioned higher morbidity and mortality in older adults during heat waves. The broad objective of this work is to determine the impact of ambient heat exposure on myocardial blood flow and flow reserve in young and older adults. Aim 1 will test the hypothesis that older adults exhibit attenuated myocardial flow reserve compared to young adults during heat stress. Aim 2 will determine if the percent of maximal myocardial flow reserve (assess via vasodilator stress) during heat exposure is higher in older adults compared to young adults. The expected outcome from this body of work will improve our understanding of the consequences of aging on cardiovascular responses to ambient heat stress.
Eligibility Criteria
Inclusion Criteria: * Healthy male and female individuals * 18-35 years or 65+ years of age * Free of any underlying moderate to serious medical conditions Exclusion Criteria: * Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia. * Taking of any medications (such as beta blockers and non-dihydropyridine calcium channel blockers) that have known influences on either cardiac function or sweating responses. * Abnormalities detected on routine screening. * Current smokers, as well as individuals who regularly smoked within the past 3 years. * Body mass index of greater than 30 kg/m\^2 * Pregnant individuals
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06842784 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Aging. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06842784 currently recruiting?
Yes, NCT06842784 is actively recruiting participants. Contact the research team at ZacharyMckenna@texashealth.org for enrollment information.
Where is the NCT06842784 trial being conducted?
This trial is being conducted at Dallas, United States.
Who is sponsoring the NCT06842784 clinical trial?
NCT06842784 is sponsored by University of Texas Southwestern Medical Center. The trial plans to enroll 24 participants.