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Recruiting Phase 2, Phase 3 NCT06396247

NCT06396247 Impact of Brief Daily Functional Resistance Training on Lower Extremity Physical Performance

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Clinical Trial Summary
NCT ID NCT06396247
Status Recruiting
Phase Phase 2, Phase 3
Sponsor Milton S. Hershey Medical Center
Condition Mobility Limitation
Study Type INTERVENTIONAL
Enrollment 360 participants
Start Date 2025-04-09
Primary Completion 2028-01

Eligibility & Interventions

Sex All sexes
Min Age 65 Years
Max Age N/A
Study Type INTERVENTIONAL
Interventions
Functional Activity Strength Training

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.

This trial targets 360 participants in total. It began in 2025-04-09 with a primary completion date of 2028-01.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

In this study, we will randomly assign 360 older adults to 12 months of 5 minutes per day of functional resistance training or to a delayed treatment control condition, and measure the impact of the training on measures of lower extremity performance and walking ability.

Eligibility Criteria

Inclusion Criteria: * Self-reported difficulty or inability to walk ¼ mile Exclusion Criteria: * Chest pain on the PAR-Q

Contact & Investigator

Central Contact

Christopher Sciamanna, MD, MPH

✉ cns10@psu.edu

📞 610-585-9765

Principal Investigator

Maggie Nellissery, Ph.D.

STUDY CHAIR

National Institute on Aging (NIA)

Frequently Asked Questions

Who can join the NCT06396247 clinical trial?

This trial is open to participants of all sexes, aged 65 Years or older, studying Mobility Limitation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

What phase is the NCT06396247 trial and what does that mean for participants?

Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.

Is NCT06396247 currently recruiting?

Yes, NCT06396247 is actively recruiting participants. Contact the research team at cns10@psu.edu for enrollment information.

Where is the NCT06396247 trial being conducted?

This trial is being conducted at Hershey, United States, Pittsburgh, United States.

Who is sponsoring the NCT06396247 clinical trial?

NCT06396247 is sponsored by Milton S. Hershey Medical Center. The principal investigator is Maggie Nellissery, Ph.D. at National Institute on Aging (NIA). The trial plans to enroll 360 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology